{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:10:01Z","timestamp":1723119001792},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Proinflammatory (TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and NO) and antiinflammatory (IL\u201010, CO) levels were assayed in serum, liver,\nand small bowel in order to verify a hypothetic inflammatory etiopathogeny of portal hypertension that could be the cause of its evolutive heterogeneity. Male Wistar rats were divided into one control group (<jats:italic>n<\/jats:italic> = 11) and one group with a triple stenosing ligation of the portal vein (<jats:italic>n<\/jats:italic> = 23) after 28 days of evolution. In one subgroup of portal hypertensive rats,\nportal pressure, collateral venous circulation, mesenteric vasculopathy, and liver and spleen weights were determined. In the remaining rats with portal hypertension TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and IL\u201010 were quantified in liver and ileum by enzyme\u2010linked immunosorbent assay. NO synthase activity was studied in liver and ileum. CO and NO were measured in portal and systemic blood by spectrophotometry and Griess reaction, respectively. Portal hypertensive rats with mayor spleen weight show hepatomegaly and mayor development of collateral circulation. Ileum release of IL\u201010 (0.30 \u00b1 0.12 versus 0.14 \u00b1 0.02\u2009pmol\/mg protein; <jats:italic>P<\/jats:italic> &lt; .01) is associated with a liver production of both proinflammatory mediators (TNF\u2010<jats:italic>\u03b1<\/jats:italic>: 2 \u00b1 0.21 versus 1.32 \u00b1 0.60\u2009pmol\/mg protein; <jats:italic>P<\/jats:italic> &lt; .05, IL\u20101<jats:italic>\u03b2<\/jats:italic>: 19.17 \u00b1 2.87 versus 5.96 \u00b1 1.84pmol\/mg\nprotein; <jats:italic>P<\/jats:italic> = .005, and NO: 132.10 \u00b1 34.72 versus 61.05 \u00b1 8.30nmol\/mL; <jats:italic>P<\/jats:italic> = .005) and an antiinflammatory mediator (CO: 6.49 \u00b1 2.99 versus 3.03 \u00b1 1.59pmol\/mL; <jats:italic>P<\/jats:italic> = .005). In short\u2010term prehepatic portal hypertension a gut\u2010liver inflammatory loop, which could be fundamental in the regulation both of the portal pressure and of its complications,\ncould be proposed.<\/jats:p>","DOI":"10.1155\/mi.2005.101","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T14:21:29Z","timestamp":1118326889000},"page":"101-111","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Proinflammatory Liver and Antiinflammatory Intestinal Mediators Involved in Portal Hypertensive Rats"],"prefix":"10.1155","volume":"2005","author":[{"given":"Maria Angeles","family":"Aller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cruz","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dolores","family":"Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paz","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2005\/387427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MI.2005.101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:27:59Z","timestamp":1723116479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MI.2005.101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/MI.2005.101"],"URL":"https:\/\/doi.org\/10.1155\/mi.2005.101","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"type":"print","value":"0962-9351"},{"type":"electronic","value":"1466-1861"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2004-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}