{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:26:13Z","timestamp":1791307573902,"version":"4.3.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF\u2010<jats:italic>\u03ba<\/jats:italic>B in rats with colitis.  Rat colitis model was established by TNBS enema. NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, ICAM\u20101, and I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic> in colon tissue were examined by immunohistochemistry, EMSA, RT\u2010PCR, and Western blot analysis.  Expression of proinflammatory molecule and activation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B were upregulated and I<jats:italic>\u03ba<\/jats:italic>B level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF\u2010<jats:italic>\u03ba<\/jats:italic>B inhibition and blockade of I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic> degradation.<\/jats:p>","DOI":"10.1155\/mi.2005.185","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T13:02:48Z","timestamp":1125493368000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Melatonin Reduces Inflammatory Injury through Inhibiting NF\u2010<i>\u03ba<\/i>B Activation in Rats with Colitis"],"prefix":"10.1155","volume":"2005","author":[{"given":"Jun-Hua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Sheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,31]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2005\/585189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MI.2005.185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:28:45Z","timestamp":1723080525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MI.2005.185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/MI.2005.185"],"URL":"https:\/\/doi.org\/10.1155\/mi.2005.185","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}