{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:27:54Z","timestamp":1791019674675,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["503-119-1"],"award-info":[{"award-number":["503-119-1"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["502-11-089"],"award-info":[{"award-number":["502-11-089"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["503-119-1"],"award-info":[{"award-number":["503-119-1"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["502-11-089"],"award-info":[{"award-number":["502-11-089"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Dermatitis herpetiformis (DH) is a subepidermal autoimmune\ndisease characterized by skin and intestinal lesions consistent\nwith coeliac disease. There are also some data that\nmetalloproteinases (MMPs) are involved in the development of skin\nlesions in DH, however their exact role in this process is not\nfully understood. The aim of the study was to investigate whether\nMMPs and their inhibitors are involved in pathogenesis of DH. Skin\nbiopsies were taken from 13 patients with active DH and from 10\nhealthy subjects. The localization and expression of MMPs and\nTIMPs were examined by immunohistochemistry. MMPs expression was\ndetected in basal keratinocytes and in the whole epidermis in all\nof the DH subjects. Neutrophils in microabscesses and in blister fluid\nwere also positive for MMPs. Expression of TIMPs was moderate or\nweak in all examined biopsies. Our results allow us to conclude\nthat imbalance between these enzymes takes an important role in\nthe pathogenesis of DH.<\/jats:p>","DOI":"10.1155\/mi.2005.373","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T07:55:05Z","timestamp":1135151705000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Imbalance Between Metalloproteinases and Their Tissue InhibitorsIs Involved in the Pathogenesis of Dermatitis Herpetiformis"],"prefix":"10.1155","volume":"2005","author":[{"given":"Agnieszka","family":"Zebrowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sysa-Jedrzejowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Kobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Waszczykowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2005\/585323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/MI.2005.373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:00:49Z","timestamp":1723096849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/MI.2005.373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/MI.2005.373"],"URL":"https:\/\/doi.org\/10.1155\/mi.2005.373","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}