{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:03:12Z","timestamp":1773000192047,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060421"],"award-info":[{"award-number":["82060421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis, which has been extensively investigated, yet effective treatments remain lacking. Splicing factor proline and glutamine rich (SFPQ) is known to play a crucial role in neurodegenerative diseases, including antioxidant\u2010related functions and regulating gene expression within brain neurons. However, the specific role of SFPQ in AD pathology is not well understood. In this study, an AD mouse model was established through lateral ventricular injection of amyloid\u2010beta\n                    <jats:sub>1\u201342<\/jats:sub>\n                    (A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>1\u201342<\/jats:sub>\n                    ). Subsequently, adeno\u2010associated virus was administered to overexpress SFPQ in the hippocampus of AD mice. The results demonstrate that SFPQ overexpression improves recognition and memory in AD mice, while reducing AD\u2010related marker proteins such as amyloid precursor protein (APP) and Tau. Additionally, synaptic and memory\u2010associated proteins, as well as antioxidant proteins like glutathione S\u2010transferase (GST) and heme oxygenase\u20101 (HO\u20101), were upregulated. The ratio of antiapoptotic protein Bcl\u20102 to proapoptotic protein Bax also increased. Furthermore, phosphorylated phosphoinositide 3\u2010kinase (p\u2010PI3K)\/PI3K and phosphorylated protein kinase B (p\u2010AKT)\/AKT ratios were elevated, indicating activation of the PI3K\/AKT signaling pathway. These findings suggest that SFPQ may serve as a promising molecular target for the prevention and treatment of AD.\n                  <\/jats:p>","DOI":"10.1155\/np\/3934591","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T02:48:46Z","timestamp":1738118926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overexpression of SFPQ Improves Cognition and Memory in AD 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