{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:07:20Z","timestamp":1788937640209,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":250,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860180"],"award-info":[{"award-number":["81860180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Amblyopia is a neurodevelopmental disorder for which effective treatments in adults are limited due to reduced cortical plasticity. Environmental enrichment (EE) can partially restore this plasticity, but the underlying molecular mechanisms remain unclear. This study investigated whether the miR\u2010132\/HDAC3 pathway is associated with EE\u2010induced visual recovery in adult amblyopic mice. An adult amblyopia model (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200964) was established via monocular deprivation (MD). Amblyopic mice were assigned to untreated, standard housing (SH), or EE groups, with normal mice as controls. Visual function was assessed using flash visual evoked potentials (fVEP), and molecular analyses of miR\u2010132 and HDAC3 in the primary visual cortex (V1) were performed. In vitro studies included a dual\u2010luciferase assay to verify miR\u2010132\u2010HDAC3 targeting and evaluated the effects of miR\u2010132\/HDAC3 overexpression on cortical neurons. Compared to SH, EE\u2010reared amblyopic mice showed (1) increased N1\u2010P2 wave amplitude in fVEP and (2) upregulated miR\u2010132 and downregulated HDAC3 in V1. In vitro, HDAC3 was confirmed as a direct miR\u2010132 target, and miR\u2010132 overexpression suppressed HDAC3 while promoting structural remodeling in visual cortical neurons. These findings suggest that the miR\u2010132\/HDAC3 pathway potentially contributes to EE\u2010induced visual restoration in adult amblyopia.\n                  <\/jats:p>","DOI":"10.1155\/np\/6559412","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:47:16Z","timestamp":1788936436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental Enrichment Enhances Visual Function in Adult Amblyopia: Association With miR\u2010132\/HDAC3 Regulation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4957-3371","authenticated-orcid":false,"given":"Suzhen","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-0852","authenticated-orcid":false,"given":"Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-022-00571-2"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2021.05.010"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.1003"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009022"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6723"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.10.001"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2023.107840"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2023.114375"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1899"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034815"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.08.033"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-023-01265-9"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30337"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90319-7"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.264440"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.05.009"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490330402"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902122RR"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05337-6"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113515"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6771999"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044558"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1256744"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14231"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.036"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109651"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5653180"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148933"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201387637"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.06.025"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.834"},{"key":"e_1_2_11_32_2","first-page":"573","article-title":"Expression Levels of miRNA132 in Depression Patients and Chronic Unpredictable Mild Stress Rats","volume":"42","author":"Xu X.","year":"2020","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 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