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The amygdala is a critical hub for emotion\u2013visceral integration and exhibits functional heterogeneity across its subregions. However, subregion\u2010specific network alterations in dIBS remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine IBS patients and 36 demographically matched healthy controls (HCs) completed resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) and clinical assessments. Patients were stratified into dIBS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) and nondepressive IBS (ndIBS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) groups. Bilateral lateral amygdala (lAmyg) and medial amygdala (mAmyg) were selected as seeds for graph\u2010theoretical nodal metrics and seed\u2010based functional connectivity (FC) analyses. One\u2010way analysis of covariance with post hoc comparisons was performed to assess intergroup differences. Correlation, mediation, and receiver operating characteristic (ROC) analyses were further conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with ndIBS patients, dIBS patients exhibited increased degree centrality (DC) and nodal efficiency (Ne) in the left lAmyg, which were positively associated with depressive symptom severity. In addition, dIBS patients showed widespread hypoconnectivity between amygdala subregions and prefrontal and sensorimotor regions, including the medial superior frontal gyrus, postcentral gyrus, and thalamus. These FC alterations were correlated with clinical symptoms severity. Notably, the mAmyg\u2010related FC in superior frontal gyrus and thalamus showed mediation effects linking gastrointestinal symptoms and depressive symptoms and exhibited high accuracy in distinguishing dIBS from ndIBS (area under the curves, AUCs\u2009&gt;\u20090.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aberrant nodal properties and disrupted connectivity of amygdala subregions may reflect altered emotion\u2013visceral integration in dIBS. These findings provide neuroimaging evidence for brain\u2013gut interaction abnormalities in dIBS and suggest that amygdala subregional networks may serve as potential markers for symptom stratification and targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/np\/7203336","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:06:36Z","timestamp":1784541996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant Nodal Topological Properties and Functional Connectivity of Amygdala Subregions Underlie Emotion\u2013Visceral Integration Impairment in IBS With Depressive Symptoms"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7680-3931","authenticated-orcid":false,"given":"Yidan","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2280-7443","authenticated-orcid":false,"given":"Rongting","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4305-0698","authenticated-orcid":false,"given":"Liqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8039-6852","authenticated-orcid":false,"given":"Yihan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0530-3565","authenticated-orcid":false,"given":"Ruoyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-0976","authenticated-orcid":false,"given":"Yun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3792-5731","authenticated-orcid":false,"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-7098","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31548-8"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15325"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0286-8"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12938"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2026.111784"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108052"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042320-014032"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-024-00964-w"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2023.61"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2062-23.2024"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9478-1"},{"key":"e_1_2_13_13_2","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1073\/pnas.1910842117","article-title":"Individual-Specific Functional Connectivity of the Amygdala: A Substrate for Precision Psychiatry[J]","volume":"117","author":"Sylvester C.M","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.042"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045906"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2025"},{"key":"e_1_2_13_18_2","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.144046","article-title":"Vagal Gut-Brain Signaling Mediates Amygdaloid Plasticity, Affect, and Pain in a Functional Dyspepsia Model","volume":"6","author":"Cordner Z. 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