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Key gaps include the temporary loss of spinal reflexes during spinal shock and the dynamics of \u201cinjury potentials,\u201d which spread rapidly from the impact site, similar to cortical spreading depression (CSD). While traditionally spinal shock has been viewed as unavoidable, targeted interventions could potentially mitigate SCI pathology and improve recovery. Additionally, immediate changes in brain circuitry post\u2010SCI remain debated, with limited markers for assessing early neuronal and glial damage. Early supraspinal biomarkers, including neuron\u2010specific enolase (NSE), S\u2010100\u03b2, and microRNAs, may further refine injury severity assessments. The potential for spontaneous spinal circuit repair is often underestimated, yet molecular evidence suggests preserved interneuronal networks may support functional reconnections. Pediatric SCIs show superior self\u2010repair, highlighting unique plasticity mechanisms that could be leveraged for therapeutic benefit. While in vivo models mimic human pathology, ex vivo neonatal rodent models allow continuous electrophysiological recordings of spontaneous and evoked neuronal activity during SCI, revealing how lumbar locomotor circuits integrate afferent input post\u2010injury. Using an ex vivo neonatal SCI model, we demonstrate real\u2010time network changes in the brain and spinal cord. Our model enables modulation of the extracellular ionic environment and afferent stimulation. By integrating ex vivo models, molecular biomarkers, and insights from early developmental stages, we can uncover novel mechanisms of an acute SCI or refine neuromodulatory strategies to promote recovery of functions.<\/jats:p>","DOI":"10.1155\/np\/7460038","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:55:56Z","timestamp":1776426956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5787-1785","authenticated-orcid":false,"given":"Mariia E.","family":"Ermolaeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-4427","authenticated-orcid":false,"given":"Atiyeh","family":"Mohammadshirazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-6873","authenticated-orcid":false,"given":"Dimitry","family":"Sayenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-1438","authenticated-orcid":false,"given":"Giuliano","family":"Taccola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_17_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw080"},{"key":"e_1_2_17_2_2","volume-title":"Spinal Cord Injury: A Global Perspective","author":"World Health Organization (WHO)","year":"2024"},{"key":"e_1_2_17_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12071126"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094858"},{"key":"e_1_2_17_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114178"},{"key":"e_1_2_17_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00333"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06094-5"},{"key":"e_1_2_17_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2014.12.007"},{"key":"e_1_2_17_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00282"},{"key":"e_1_2_17_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2014.965208"},{"key":"e_1_2_17_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.1.0015"},{"key":"e_1_2_17_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6785"},{"key":"e_1_2_17_13_2","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2011-1848"},{"key":"e_1_2_17_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.231"},{"key":"e_1_2_17_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/095952874002300111"},{"key":"e_1_2_17_16_2","doi-asserted-by":"crossref","DOI":"10.1177\/095952879908200122","article-title":"Address on the Spinal Animal","volume":"82","author":"Sherrington C. 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