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However, the reported results are inconsistent. The aim of this study was to conduct a meta\u2010analysis to identify consistent patterns of brain activity alterations in adolescent nsMDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted across PubMed, Web of Science, Embase, Google Scholar, Wanfang, and CNKI for rs\u2010fMRI studies that compared nsMDD patients with healthy controls (HCs), up to June 30, 2025. Significant cluster coordinates were extracted for comprehensive analysis. We utilized regional homogeneity (ReHo) and amplitude of low\u2010frequency fluctuations (ALFFs) analyses. Activation likelihood estimation (ALE) was used to identify regions of aberrant spontaneous neural activity in adolescent nsMDD compared to HCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies (249 adolescent nsMDD and 278 HCs) were included. The ALE meta\u2010analysis revealed increased activity in the left lingual gyrus (LING; Brodmann area [BA] 18) in adolescent nsMDD compared to HCs (voxel size\u2009=\u2009200\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Decreased activity was observed in the right posterior cingulate cortex (PCC; BA 29) in adolescent nsMDD compared to HCs (voxel size\u2009=\u2009360\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Jackknife sensitivity analyses demonstrated robust reproducibility in five of eight tests for the left LING and in six of eight tests for the right PCC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis confirms consistent alterations in specific brain regions in adolescent nsMDD, highlighting the potential of rs\u2010fMRI to refine diagnostic and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/np\/7885279","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:43:03Z","timestamp":1763116983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self\u2010Injury: A Resting\u2010State Functional Magnetic Resonance Imaging Meta\u2010Analysis"],"prefix":"10.1155","volume":"2025","author":[{"given":"Yanping","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3365-7628","authenticated-orcid":false,"given":"Zuli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-8441","authenticated-orcid":false,"given":"Yongzhe","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01738-y"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12333"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.03.074"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1434958"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115476"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30030-6"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115638"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2018.02.012"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13034-024-00801-4"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1109334"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-024-01858-0"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.06.009"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1359400"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/13811118.2016.1158679"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03183-x"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1177227"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2018.0152"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/sltb.12331"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.03.084"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2024.0052"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100664"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.01.034"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03276-y"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.925672"},{"key":"e_1_2_11_25_2","article-title":"Investigation of the Correlation Between Resting fMRI and Impulsivity, Emotional Regulation of First-Episode MDD Adolescents With Non-Suicidal Self-Injury","volume":"2022","author":"Liang L. 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