{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:12:26Z","timestamp":1783696346943,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":190,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2341003"],"award-info":[{"award-number":["T2341003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the feasibility, safety, and preliminary effects of individual music therapy (IMT) on electroencephalography (EEG) cortical activation in patients with minimally conscious state (MCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This study was pilot randomized, single\u2010blind, and blank\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>China Rehabilitation Research Center (CRRC), Beijing, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Sixty\u2010two MCS patients (diagnosed by Coma Recovery Scale\u2010Revised [CRS\u2010R]) were enrolled between March 2024 and July 2025; 43 completed the trial and were randomized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      The experimental group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) received 12\u2010week individualized music therapy (30\u2010min sessions, five times per week) delivered by a certified music therapist.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Comparator<\/jats:title>\n                    <jats:p>\n                      The control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) received routine treatment and rehabilitation training without music intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>The change in EEG spectral power (alpha band, 8\u201313\u2009Hz) over right\u2010hemisphere frontocentral regions from baseline (T1) to post\u2010intervention (T2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IMT group showed significantly increased alpha power over the right lateral prefrontal cortex, precentral gyrus, and central sulcus at T2 compared T1 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05; descriptive comparison), whereas no such change was observed in the control group. No adverse events occurred in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IMT is feasible and safe in medically fragile MCS patients and may induce right\u2010hemisphere cortical activation. These pilot findings are hypothesis\u2010generating and require confirmation in larger, adequately powered trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2500114153, MR\u201011\u201024\u2010014167<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/np\/8832006","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:12:26Z","timestamp":1783692746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Individualized Music Therapy in Patients With MCS: A Pilot Study on EEG"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-2958","authenticated-orcid":false,"given":"Xiaoying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-6246","authenticated-orcid":false,"given":"Yunlei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-3431","authenticated-orcid":false,"given":"Zuliyaer","family":"Talifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7110-3983","authenticated-orcid":false,"given":"Qingqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6518-2035","authenticated-orcid":false,"given":"Jiayi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-4685","authenticated-orcid":false,"given":"Xiaobing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8686-2236","authenticated-orcid":false,"given":"Xiaoxia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511780"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-09438-z"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65360-4"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf349"},{"key":"e_1_2_13_5_2","doi-asserted-by":"crossref","unstructured":"WarrenA. 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