{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:00:12Z","timestamp":1791478812787,"version":"4.3.4"},"reference-count":123,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":278,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2024-548"],"award-info":[{"award-number":["075-15-2024-548"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a prevalent neurodegenerative disorder characterized by A\u03b2\u2010amyloid accumulation and cognitive decline. Despite extensive research, effective treatments remain elusive. Astrocytes, the most abundant glial cells, play a crucial role in synaptic transmission, neuronal excitability, and plasticity. In AD, astrocytes become reactive, exhibiting aberrant calcium signaling and altered neurotransmitter release, making them promising targets for disease\u2010modifying therapies. To address this, we explored designer receptors exclusively activated by designer drugs (DREADDs), specifically the hM3D(Gq) receptor, which selectively modulates intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels in astrocytes upon activation by clozapine\u2010N\u2010oxide (CNO). Using daily CNO administration in 8\u2010month\u2010old 5xFAD mice, we observed a significant enhancement of impaired long\u2010term potentiation formation, accompanied by cognitive improvements in the fear conditioning (FC) and Morris water maze (MWM) tests. Additionally, anxiety levels and social preference deficits in 5xFAD mice were fully restored following astrocytic activity modulation. Importantly, this approach reduced A\u03b2\u2010amyloid plaque burden and demonstrated a trend toward mitigating astrocytic reactivity, further highlighting its therapeutic potential. Our findings suggest that targeting astrocytic activity via Gq\u2010coupled receptors represents a novel and promising strategy for AD treatment, offering a noninvasive and effective approach to mitigating disease progression.\n                  <\/jats:p>","DOI":"10.1155\/np\/9880933","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:05:21Z","timestamp":1759737921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Neurodegeneration in Alzheimer\u2019s Disease Mice Model 5xFAD"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-7571","authenticated-orcid":false,"given":"Evgenii","family":"Gerasimov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-5458","authenticated-orcid":false,"given":"Anastasia","family":"Bolshakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6951","authenticated-orcid":false,"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-703X","authenticated-orcid":false,"given":"Olga","family":"Vlasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00221"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050892"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00177.x"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-2"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/748212"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1064-09.2009"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120861"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001694"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.08.075"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1188-16.2016"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73849-z"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.12.022"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135843"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.06.015"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01349-6"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1722"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0080-6"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15878"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1937-8"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00451"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23486"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.10.005"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.002"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00059"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00641-1"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720511794604543"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"},{"key":"e_1_2_14_30_2","doi-asserted-by":"crossref","unstructured":"MitroshinaE. 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