{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:09:19Z","timestamp":1760645359577},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":3287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":3287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS13230"],"award-info":[{"award-number":["NS13230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BNS 8801726"],"award-info":[{"award-number":["BNS 8801726"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS13230"],"award-info":[{"award-number":["NS13230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BNS 8801726"],"award-info":[{"award-number":["BNS 8801726"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>Pineal glands from neonatal (0\u20101 day) Long\u2010Evans\nblack\u2010hooded rats were transplanted into the cerebral\nhemispheres of litter mates for periods of 1 to 5.5\nmonths. Grafts exhibited differentiated pinealocytes\nthat were intensely immunoreactive for serotonin.\nTransplant vasculature was permeable to endogenous\nIgG, comprised fenestrated endothelia with wide\npericapillary spaces typical of <jats:italic>in situ<\/jats:italic> glands, and had\na volume density intermediate to that of surrounding\ncortex and <jats:italic>in situ<\/jats:italic> pineals. Along the periphery,\ntransplant capillaries tended to have continuous\nendothelia similar to those of host cortex. This peripheral zone was impermeable to endogenous IgG\nand appeared to increase in size in older grafts. The\npresence of noradrenergic\u2010like fibers within the\nperivascular compartment suggested that transplants\nwere innervated by peripheral sympathetic neurons\nfrom the superior cervical ganglia. In animals which\nhad been superior cervical ganglionectomized, noradrenergic\u2010like\nfibers were absent or degenerating.\nNeural regulation of transplant metabolic activity was\nsuggested by the increased frequency of pinealocyte\nsynaptic ribbons in denervated grafts. These findings\nare consistent with the hypothesis that factors from\nboth graft and host influence vasculature physiology\nand differentiation in neural transplants. Furthermore,\ngrafts appeared to receive appropriate neural\ninput from the peripheral sympathetic system.<\/jats:p>","DOI":"10.1155\/np.1991.113","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"113-124","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pineal Gland Transplants into the Cerebral Hemisphere of Newborn Rats: A Study of the Blood Brain Barrier and Innervation"],"prefix":"10.1155","volume":"2","author":[{"given":"J. A.","family":"McNulty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. E.","family":"Alones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. S.","family":"Klausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Swenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/1991\/509452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.1991.113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T14:07:36Z","timestamp":1723126056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.1991.113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1155\/NP.1991.113"],"URL":"https:\/\/doi.org\/10.1155\/np.1991.113","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"type":"print","value":"2090-5904"},{"type":"electronic","value":"1687-5443"}],"subject":[],"published":{"date-parts":[[1991,1]]},"assertion":[{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}