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Although cell implants had minimal effect\non the basal response to thermal nociceptive\nstimuli, administration of the \u00df<jats:sub>2<\/jats:sub>\u2010adrenergic\nagonist isoproterenol produced antinociception\nin the cell\u2010implanted group but not in the\ncontrol group. The antinociceptive effect of\nisoproterenol was dose\u2010related and could be\nblocked by the opioid antagonist naloxone.\nImmunohistochemical analysis of spinal cords\nrevealed the presence of enkephalin\u2010negative\ncells surrounding the spinal cord of rats\nreceiving AtT\u201020 cell implants, and enkephalinpositive\ncells surrounding the spinal cord of rats.\nreceiving AtT\u201020\/hENK cell implants. These\nresults suggest that opioid\u2010releasing cells\nimplanted around rat spinal cord can produce\nantinociception and may provide an alternative\ntherapy for chronic pain.<\/jats:p>","DOI":"10.1155\/np.1993.15","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antinociception Following Implantation of AtT\u201020 and GeneticallyModified AtT\u201020\/hENK Cells in Rat Spinal Cord"],"prefix":"10.1155","volume":"4","author":[{"given":"Hope H.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"McLoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/1993\/594759.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.1993.15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:55:13Z","timestamp":1723067713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.1993.15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1155\/NP.1993.15"],"URL":"https:\/\/doi.org\/10.1155\/np.1993.15","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"type":"print","value":"2090-5904"},{"type":"electronic","value":"1687-5443"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}