{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:19:36Z","timestamp":1789877976140,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Investigations in laboratory animals indicate\nthat certain drugs that influence specific neurotransmitters\ncan have profound effects on the\nrecovery process. Even small doses of some\ndrugs given after brain injury facilitate recovery\nwhile others are harmful. Preliminary clinical\nstudies suggest that the same drugs that enhance\nrecovery in laboratory animals (e.g.,\namphetamine) may have similar effects in\nhumans after stroke. In addition, some of the\ndrugs that impair recovery of function after\nfocal brain injury in laboratory animals (e.g.\nhaloperidol, benzodiazepines, clonidine,\nprazosin, phenytoin) are commonly given to\nstroke patients for coincident medical problems\nand may interfere with functional recovery in\nhumans. Until the impact of pharmacologic\nagents on the recovering brain is better\nunderstood, the available data suggest that care\nshould be exercised in the selection of drugs used\nin the treatment of the recovering stroke patient.\nPharmacologic enhancement of recovery after\nfocal brain injury may be possible in humans.<\/jats:p>","DOI":"10.1155\/np.1993.175","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"175-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Basic and Clinical Studies of Pharmacologic Effects on Recoveryfrom Brain Injury"],"prefix":"10.1155","volume":"4","author":[{"given":"Larry B.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/1993\/815469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.1993.175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:00:44Z","timestamp":1723068044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.1993.175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1155\/NP.1993.175"],"URL":"https:\/\/doi.org\/10.1155\/np.1993.175","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}