{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:55:49Z","timestamp":1792112149086,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Intravenous administration of <jats:sub>\u2009<\/jats:sub><jats:sup>15<\/jats:sup>O\u2010labeled\nwater and 6\u2010[<jats:sub>\u2009<\/jats:sub><jats:sup>18<\/jats:sup>F]\u2010L\u2010fluorodopa were used to\nassess abnormal striatal activity in monkeys\nafter long\u2010term recovery of unilateral lesions of\nthe dopaminergic nigro\u2010striatal system induced\nby the neurotoxin MPTP. PET data were\nexamined in relation to behavioral and\nbiological parameters. Cerebral blood flow and\n6\u2010[<jats:sub>\u2009<\/jats:sub><jats:sup>18<\/jats:sup>F]\u2010L\u2010DOPA uptake were found to be\nsignificantly reduced in the lesioned striatum,\ncompared to the unaffected side and to normal\ncontrols. There was no correlation between\ncerebral blood flow and any of the behavioral\nparameters. The uptake rate constant of <jats:sub>\u2009<\/jats:sub><jats:sup>18<\/jats:sup>F\u2010DOPA from blood to striatum and the ratios of\nstriatum to occipital areas were highly\ncorrelated to the concentrations of homovanillic\nacid in the cerebrospinal fluid of the same\nanimals but not to the rotational behavior. This\nMPTP\u2010inducedmodei of striatal dopamine\ndeficiency in primates presents similarities with\nidiopathic Parkinson\u2032s disease and may be used\nto evaluate the effects of dopaminergic lesions\nand transplants on brain function.<\/jats:p>","DOI":"10.1155\/np.1993.27","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"27-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["6\u2010[<sub>\u2009<\/sub><sup>18<\/sup>F]Fluoro\u2010L\u2010DOPA and Cerebral Blood Flow in UnilaterallyMPTP\u2010Treated Monkeys"],"prefix":"10.1155","volume":"4","author":[{"given":"Doris J.","family":"Doudet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Jed","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Cannon-Spoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Suddath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/1993\/373089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.1993.27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:55:11Z","timestamp":1723067711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.1993.27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1155\/NP.1993.27"],"URL":"https:\/\/doi.org\/10.1155\/np.1993.27","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}