{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:10:02Z","timestamp":1723097402165},"reference-count":0,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>In electrophysiological terms, experimental\nmodels of durable information storage in the\nbrain include long\u2010term potentiation (LTP),\nlong\u2010term depression, and kindling. Protein\nsynthesis correlates with these enduring\nprocesses. We propose a fourth example of\nlong\u2010lasting information storage in the brain,\nwhich we call the GABA\u2010withdrawal syndrome\n(GWS). In rats, withdrawal of a chronic\nintracortical infusion of GABA, a ubiquitous\ninhibitory neurotransmitter, induced epileptogenesis\nat the infusion site. This overt GWS lasted\nfor days. Anisomycin, a protein synthesis\ninhibitor, prevented the appearance of GWS\n<jats:italic>in vivo<\/jats:italic>. Hippocampal and neocortical slices\nshowed a similar post\u2010GABA hyperexcitability\n<jats:italic>in vitro<\/jats:italic> and an enhanced susceptibility to LTP\ninduction. One to four months after the epileptic\nbehavior disappeared, systemic administration\nof a subconvulsant dose of pentylenetetrazol\nproduced the reappearance of paroxysmal\nactivity. The long\u2010lasting effects of tonic\nGABA<jats:sub>A<\/jats:sub>\nreceptor stimulation may be involved\nin long\u2010term information storage processes at\nthe cortical level, whereas the cessation of\nGABA<jats:sub>A<\/jats:sub>\n receptor stimulation may be involved  in chronic pathological conditions, such as\nepilepsy. Furthermore, we propose that GWS\nmay represent a common key factor in the\naddiction to GABAergic agents (for example,\nbarbiturates, benzodiazepines, and ethanol).\nGWS represents a novel form of neurono\u2010glial\nplasticity. The mechanisms of this phenomenon\nremain to be understood.<\/jats:p>","DOI":"10.1155\/np.2000.1","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"1-8","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat"],"prefix":"10.1155","volume":"7","author":[{"given":"Teresa","family":"Montiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Arango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Calixto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Casasola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sim\u00f3n","family":"Brailowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2000\/739320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.2000.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:54:50Z","timestamp":1723096490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.2000.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/NP.2000.1"],"URL":"https:\/\/doi.org\/10.1155\/np.2000.1","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"type":"print","value":"2090-5904"},{"type":"electronic","value":"1687-5443"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2000-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}