{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:10:01Z","timestamp":1723097401619},"reference-count":0,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The GABA\u2010withdrawal syndrome (GWS)\nis a model of local status epilepticus following\nthe interruption of a chronic GABA infusion\ninto the rat somatomotor cortex. GWS is\ncharacterized by focal epileptic electroencephalographic\ndischarges and associated contralateral\nmyoclonus. In neocorticai slices obtained\nfrom GWS rats, most neurons recorded in the\nGABA\u2010infused area are pyramidal neurons\npresenting bursting properties. The bursts are\ninduced by white\u2010matter stimulation and\/or\nintracellular depolarizing current injection\nand correlate with a decrease of cellular\nsensitivity to GABA, caused by its prolonged\ninfusion. This effect is related to a calcium\ninflux that may reduce the GABA<jats:sub>A<\/jats:sub>\n receptormediated\ninward current and is responsible\nfor the bursting properties. Here we present\nevidence for the involvement of calcium\u2010 and\nNMDA\u2010induced currents in burst genesis. We\nalso report modulatory effects of noradrenaline\nappearing as changes on firing patterns of\nbursting and nonbursting cells. Complementary\nhistochemical data reveal the existence of a\nlocal noradrenergic hyperinnervation and an\nectopic expression of tyrosine hydroxylase\nmRNAs in the epileptic zone.\n<\/jats:p>","DOI":"10.1155\/np.2000.9","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:22:50Z","timestamp":1173950570000},"page":"9-18","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The GABA\u2010Withdrawal Syndrome: A Model of Local Status Epilepticus"],"prefix":"10.1155","volume":"7","author":[{"given":"Carmen","family":"Silva-Barrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Champagnat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Menini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2000\/968906.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/NP.2000.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:54:35Z","timestamp":1723096475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/NP.2000.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/NP.2000.9"],"URL":"https:\/\/doi.org\/10.1155\/np.2000.9","archive":["Portico"],"relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"type":"print","value":"2090-5904"},{"type":"electronic","value":"1687-5443"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2000-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}