{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:13:29Z","timestamp":1783577609529,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":188,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurology Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) causes physical as well as psychosocial disability in young adults. Various sleep\u2010related disorders have been reported in patients with multiple sclerosis (pwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We determined the frequency and patterns of various sleep\u2010related disorders in pwMS and correlated those with the sleep quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an IRB\u2010approved study done at King Abdulaziz Medical City, MNGHA, Riyadh, KSA. Informed consent was obtained. Validated questionnaires including Pittsburgh Sleep Quality Index (PSQI), Sleep Disorders Questionnaire (SDQ), and STOP\u2010BANG Questionnaire were used. Data were analyzed using SPSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 169 pwMS were included; 116 (69%) were females. Mean age was 35\u2009\u00b1\u200910\u2009years; mean BMI was 27.6\u2009\u00b1\u200916.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Almost half (47%) of the patients were employed, and most worked in day shift (85%). Caffeinated beverages were used by 87%; 16% were smokers. Relapsing remitting MS was the commonest type in 93%; 82% were using disease\u2010modifying therapy (DMT). Sleep\u2010related medications were used by 18%. Disability measured by EDSS was mild in 64%, moderate in 18%, and severe in 18%. Poor quality of sleep was reported by 74% (mean PSQI 7.8\u2009\u00b1\u20093.9). Circadian rhythm disorders were reported in 22%, psychiatric disorders in 18%, and parasomnias in 14%; 4% had high risk for sleep apnea. Psychiatric disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and movement disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) were more frequently reported in women. Risk for insomnia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), circadian rhythm disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), and psychiatric disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) were associated with poor sleep quality. Type of MS and current treatment did not affect the frequency of sleep disorders or sleep quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our cohort of pwMS, sleep\u2010related disorders were common. Risk for insomnia, psychiatric disorders, and circadian rhythm disorders were associated with poor sleep quality. Certain disorders showed a trend toward female preponderance. Disease severity and use of DMTs did not affect sleep quality in our cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/nri\/4041733","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:16:32Z","timestamp":1783574192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Sleep\u2010Related Disorders on the Sleep Quality in Patients With Multiple Sclerosis in a Saudi Cohort"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-1840","authenticated-orcid":false,"given":"Ismail A.","family":"Khatri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0152-0452","authenticated-orcid":false,"given":"Khalid Bin","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-7340","authenticated-orcid":false,"given":"Esraa Y.","family":"Arabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-6959","authenticated-orcid":false,"given":"Ghaida A.","family":"Almusallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-4122","authenticated-orcid":false,"given":"Razan F.","family":"Alfaiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8106-5698","authenticated-orcid":false,"given":"Abeer A.","family":"Alkhathlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazish","family":"Masud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser Al","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101842"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06364-6"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1444470"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01058-x"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10304"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105014"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-329227"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.2.160"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e31816d83e4"},{"key":"e_1_2_14_11_2","article-title":"Sleep Disorders in Relapsing-Remitting Multiple Sclerosis Patients","volume":"71","author":"Mnif S.","year":"2023","journal-title":"Multiple Sclerosis and Related Disorders"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104902"},{"key":"e_1_2_14_13_2","article-title":"Assessment of Sleep Disorders in Multiple Sclerosis","volume":"15","author":"Strober L.","year":"2015","journal-title":"Current Neurology and Neuroscience Reports"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1755233"},{"key":"e_1_2_14_15_2","first-page":"329","article-title":"Sleep Disorders Among Patients With Multiple Sclerosis in Saudi Arabia","volume":"27","author":"Alosaimi F. D.","year":"2022","journal-title":"Neurosciences"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552173231194352"},{"key":"e_1_2_14_17_2","article-title":"Cognitive Behavioral Therapy Improves Sleep and Fatigue in Individuals With Multiple Sclerosis: A Pilot Randomized Controlled Trial","volume":"54","author":"Siengsukon C. F.","year":"2021","journal-title":"Multiple Sclerosis and Related Disorders"},{"key":"e_1_2_14_18_2","article-title":"Cognitive and Sleep Dysfunction in Multiple Sclerosis: A Cross-Sectional Study Using Objective Polysomnography and Subjective Scales","volume":"8","author":"Queisi M.","year":"2024","journal-title":"Sleep Science and Practice"}],"container-title":["Neurology Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/nri\/4041733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/nri\/4041733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/nri\/4041733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:16:33Z","timestamp":1783574193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/nri\/4041733"}},"subtitle":[],"editor":[{"given":"Mohd","family":"Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/nri\/4041733"],"URL":"https:\/\/doi.org\/10.1155\/nri\/4041733","archive":["Portico"],"relation":{},"ISSN":["2090-1852","2090-1860"],"issn-type":[{"value":"2090-1852","type":"print"},{"value":"2090-1860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4041733"}}