{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:28:02Z","timestamp":1778858882364,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":348,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obstetrics and Gynecology International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To validate previous age subgrouping methods and provide an optimal age reference for women planning to delay in vitro fertilization (IVF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From July 2014 to March 2018, 3012 patients that received IVF\/intracytoplasmic sperm injection (ICSI) were continuously recruited in this retrospective, single\u2010center study. We analyzed the relationships of baseline characteristics and IVF outcomes. A smooth fitting curve depicting the association of age and live birth was plotted using the generalized additive model (GAM) method. We also evaluated the association of age and live birth among different age groups (&gt; 20, \u2264 35; &gt; 35, \u2264 37; &gt; 37, \u2264 40; and &gt; 40).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, duration of infertility, and baseline follicle\u2010stimulating hormone (FSH) were significantly related to the live birth rate. The adjusted Odd Ratio (OR) value of age was 0.95 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), indicating the higher occurrence of no live birth with age increasing. The fitting curve showed that the live birth rate decreased with age. And 35.5 (34.5\u201336.5) was identified as the inflection point of the curve. The slopes before 35.5 and after 35.5 were significantly different (0.9 [0.9, 1.0],\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). When \u2264 35, live birth rate did not vary with age. For the ages of 35\u201337 and 37\u201340, the occurrence of negative outcome increased with age (aOR: 0.73 [0.53, 0.99], 0.80 [0.65, 1.00];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0441, 0.0465, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The age of 35 can be referred to as the safe time point when the IVF success rate does not decline with age. And the risk of IVF failure increases rapidly in the period of 35\u201337 and 37\u201340.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ogi\/2407539","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T08:55:08Z","timestamp":1765788908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["When to Choose In Vitro Fertilization (IVF) When Postponing Conceiving: The Age\u2010Related Risk of IVF Failure at an Advanced Age"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1695-1455","authenticated-orcid":false,"given":"Zhiyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8354","authenticated-orcid":false,"given":"Duoduo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-9723","authenticated-orcid":false,"given":"Zhengyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-5957","authenticated-orcid":false,"given":"Qi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-0652","authenticated-orcid":false,"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangZhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395272"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2015"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu056"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1338"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00327"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140779"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm243"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx026"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0414-2"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.26192"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.37558"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.0126"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml034"},{"key":"e_1_2_13_15_2","first-page":"1","article-title":"Assisted Reproductive Technology Surveillance\u2014United States, 2010","volume":"62","author":"Sunderam S.","year":"2013","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000444440.96486.61"},{"key":"e_1_2_13_17_2","unstructured":"DailyandSCT Study: Health and Development of Children of Older first-time Mothers 2008."},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmp048087"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.07.003"},{"key":"e_1_2_13_20_2","unstructured":"Centers for Disease Control and Prevention ASfRM Technology. SfAR: 2010 Assisted Reproductive Technology Fertility Clinic Success Rates Report 2012 US Department of Health and Human Services."}],"container-title":["Obstetrics and Gynecology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ogi\/2407539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ogi\/2407539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ogi\/2407539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:38:21Z","timestamp":1772973501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ogi\/2407539"}},"subtitle":[],"editor":[{"given":"Karuna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ogi\/2407539"],"URL":"https:\/\/doi.org\/10.1155\/ogi\/2407539","archive":["Portico"],"relation":{},"ISSN":["1687-9589","1687-9597"],"issn-type":[{"value":"1687-9589","type":"print"},{"value":"1687-9597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2023-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2407539"}}