{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:16:05Z","timestamp":1788329765441,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":243,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obstetrics and Gynecology International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Achieving adequate intraoperative hemostasis is critical in gynecological surgeries to reduce perioperative morbidity. Surgi\u2010oxidized regenerated cellulose (ORC) is a biodegradable hemostatic agent that controls mild to moderate bleeding. This study aimed to generate preliminary observational data on the efficacy and safety of Surgi\u2010ORC across a range of gynecological procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicentre, single\u2010arm observational study was conducted at two centres in India. A total of 28 women undergoing gynecological surgeries, including hysterectomy, myomectomy, sacrohysteropexy, cystectomy with oophorectomy, laparotomy, and recanalization, received Surgi\u2010ORC intraoperatively for bleeding control. Time to hemostasis (TTH), the association between product variants and TTH, the association of TTH across surgery types, short\u2010term safety outcomes, and surgeon\u2010reported usability were assessed. Follow\u2010ups were conducted on postoperative Days 2, 28, and 60. Subgroup analyses were considered exploratory due to the limited sample size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hemostasis was achieved in all cases, with a mean TTH of 1.3\u2009min (SD\u2009=\u20090.43). Descriptive evaluation showed broadly similar TTH values across surgery types and product variants; however, small and imbalanced subgroup sizes limited definitive conclusions. On Day 2, X\u2010ray imaging showed no radiographic abnormalities attributable to retained material and was confirmed based on clinical judgment of the radiologist and operating surgeon. No device\u2010related adverse events, complications, or short\u2010term safety concerns were identified during the study period. Most surgeons rated handling characteristics as \u201cGood\u201d across all evaluated parameters, indicating favorable usability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This observational pilot study suggests that Surgi\u2010ORC is effective in achieving hemostasis and demonstrates no short\u2010term safety concerns during the 60\u2010day follow\u2010up along with satisfactory usability characteristics in gynecological procedures. However, given the exploratory nature of analysis, single\u2010arm design, and small sample size, these findings should be interpreted cautiously, and larger comparative studies are required to further validate its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ogi\/5056815","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:52:58Z","timestamp":1788328378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Surgi\u2010ORC for Hemostasis and Safety in Gynecological Surgeries: A Multicenter Prospective Observational Pilot Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-5908","authenticated-orcid":false,"given":"Diksha","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavin","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5761-3651","authenticated-orcid":false,"given":"Shahid N.","family":"Karatela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7284-0244","authenticated-orcid":false,"given":"Piyush","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.4293\/jsls.2022.00013"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.009"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.10.081"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad361"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-08-102192-7.00016-3"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2022.11.007"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.33545\/gynae.2023.v7.i2d.1309"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.5180\/jsgoe.38.2_32"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.18229\/kocatepetip.839261"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4718457"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s454539"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2021.0021"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.78616"},{"key":"e_1_2_11_14_2","first-page":"264","volume-title":"Statistical Analyses and Methods in the Published Literature: The SAMPL Guidelines","author":"Lang T. 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