{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:00:54Z","timestamp":1781175654937,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":161,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obstetrics and Gynecology International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gestational trophoblastic diseases (GTDs) are rare trophoblastic disorders that contribute substantially to maternal morbidity. However, the epidemiology and clinical characteristics of GTD\u2010related evidence from Ethiopia remain limited and scattered. Consequently, the national burden, histopathological distribution, and clinical presentation of GTD in Ethiopia are not well defined. In response to this gap in the literature, this systematic review and meta\u2010analysis sought to quantify the pooled prevalence of GTD and to synthesize available evidence on its histopathological and clinical profiles in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Scopus, Embase, the Cochrane Library, CINAHL, and Google Scholar were systematically searched, supplemented by manual searches of local journals and institutional repositories. The study protocol was registered and implemented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) 2020 guidelines. All studies reporting the prevalence of GTD in Ethiopia up to December 5, 2025, were eligible for inclusion. To stabilize variances when pooling proportions, a random\u2010effects meta\u2010analysis was performed by using the Freeman\u2013Tukey double arcsine transformation. Publication bias and heterogeneity across studies were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies met the inclusion criteria, out of a total of 436 records collected and evaluated, comprising 121,248 women who had delivered. The pooled prevalence of GTD in Ethiopia was 0.8% (95% CI: 0.2%\u20131.3%). Hydatidiform mole was the most common histopathological subtype, with complete and partial moles accounting for 47.1% and 20.7% of cases, respectively. Vaginal bleeding was the most frequently reported clinical presentation (88.4%), followed by a uterus larger than gestational age (34.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis demonstrated that the prevalence of GTD in Ethiopia is slightly higher than estimates reported from other regions. Hydatidiform mole was the predominant histopathological subtype, and vaginal bleeding was the most common clinical presentation. These results highlight the necessity of enhancing early detection and diagnostic capacity, particularly at the primary healthcare level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ogi\/6438666","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:43:09Z","timestamp":1781174589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, Histopathologic Patterns, and Clinical Characteristics of Gestational Trophoblastic Diseases in Ethiopia: A Systematic Review and Meta\u2010Analysis Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2911-748X","authenticated-orcid":false,"given":"Abrham Tesfaye","family":"Habteyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fekadeselassie Teferi","family":"Mekonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashebir","family":"TufaTelila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_16_1_2","unstructured":"American Cancer Society About Gestational Trophoblastic Disease: What is Gestational Trophoblastic Disease? 2017 https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research."},{"key":"e_1_2_16_2_2","first-page":"208","article-title":"Management of Molar Pregnancy","volume":"26","author":"Goldstein D. 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Histopathologic Patterns of Gestational Trophoblastic Disease in Jimma University Medical Center Jimma South West Ethiopia 2019 Jimma University Jimma Ethiopia 1\u201328 A three-year retrospective study [thesis]."},{"key":"e_1_2_16_29_2","unstructured":"AlemnewS. Follow-Up and Treatment Outcome of Gestational Trophoblastic Disease Patients Admitted to St. Paul\u2019s Hospital Millennium Medical College 2018 Addis Ababa 1\u201332 St. Paul\u2019s hospital millennium medical college [thesis]."},{"key":"e_1_2_16_30_2","unstructured":"BarkadleA. Magnitude 2022 Haramaya University Harar Eastern Ethiopia 1\u201339 Associated factors and post-evacuation follow-up of gestational trophoblastic disease among deliveries in hiwot fana specialised university hospital."},{"key":"e_1_2_16_31_2","first-page":"20","article-title":"Prevalence of Gestational Trophoblastic Disease: an Institution Experience","volume":"11","author":"Ibrahim K. O. 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