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In parallel, rising rates of obesity, diabetes, and hypertension point to shared mechanisms with infertility, particularly those rooted in diet. High intake of processed sugars, especially high\u2010fructose corn syrup (HFCS), contributes to metabolic dysfunction, oxidative stress, hormonal imbalance, and inflammation, all of which can impair sperm function and disrupt the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis. Unlike glucose, fructose undergoes hepatic metabolism, fostering insulin resistance, fat accumulation, and nonalcoholic fatty liver disease (NAFLD), further aggravating reproductive risks. In this review, four models of obesity, the energy balance model (EBM), carbohydrate\u2010insulin model (CIM), obesogen model, and OBS\/REDOX model, are applied to explain how excess fructose and obesogenic exposures drive metabolic dysfunction, oxidative stress, and endocrine disruption. Collectively, these processes reduce testosterone levels, impair spermatogenesis, compromise sperm quality, and may even induce epigenetic alterations transmissible to future generations. With modern diets increasingly dominated by HFCS and ultra\u2010processed foods (UPFs), understanding fructose\u2019s role in reproductive decline is crucial for developing effective interventions. This review underscores the need for further research to clarify how dietary fructose and environmental obesogens jointly shape metabolic and reproductive health, offering insights into public health strategies aimed at protecting male fertility in the face of modern lifestyle challenges.<\/jats:p>","DOI":"10.1155\/omcl\/4433444","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:57:45Z","timestamp":1788155865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Insight Into Male Infertility: Deviation From Basic Tenets of Life"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-3435","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Nasr-Esfahani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-5996","authenticated-orcid":false,"given":"Nushin","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-964X","authenticated-orcid":false,"given":"Marziyeh","family":"Tavalaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-4831","authenticated-orcid":false,"given":"Mazdak","family":"Razi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_26_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx022"},{"key":"e_1_2_26_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2021.1917778"},{"key":"e_1_2_26_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00728-2"},{"key":"e_1_2_26_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184"},{"key":"e_1_2_26_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"e_1_2_26_6_2","volume-title":"HEARTS D: Diagnosis and Management of Type 2 Diabetes","author":"World Health Organization (WHO)","year":"2020"},{"key":"e_1_2_26_7_2","volume-title":"Guidelines for the management of dyslipidaemia in patients with diabetes mellitus: quick reference guide","author":"World Health Organization. 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