{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:32:24Z","timestamp":1773012744906,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":218,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The present study aimed to evaluate the protective effects of aqueous and ethanol extracts of\n                    <jats:italic>Tabernaemontana stapfiana<\/jats:italic>\n                    (\n                    <jats:italic>T. stapfiana<\/jats:italic>\n                    ) on cognitive disability induced by aluminum chloride (AlCl\n                    <jats:sub>3<\/jats:sub>\n                    ) in Wistar rats. Forty\u2010five Wistar rats were distributed in different groups of five animals each. Test groups were daily given AlCl\n                    <jats:sub>3<\/jats:sub>\n                    (100\u2009mg\/kg) following by the doses of the extracts for 21 days. At the end of treatment period, rats were sacrificed and the brain homogenate and serum were prepared and used to evaluate oxidative stress in brain and serum cytokines using colorimetric tests and ELISA, respectively. The findings of this study showed that reduced brain, body weight, and antioxidant enzymes (reduced glutathione [GSH], catalase [CAT], and superoxide dismutase [SOD]), while it increases oxidant biomarkers (malondiadehyde (MDA), nitric oxide (NO) and inflammatory cytokines (IL\u201010, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106). Therefore, the administration of aqueous or ethanol extracts of\n                    <jats:italic>T. stapfiana<\/jats:italic>\n                    stem bark significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001) reduced the IL\u201010, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 levels in AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010treated rats compared to non treated rats. Moreover, the extracts significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001) changed the oxidant\u2013antioxidant balance by reducing the MDA and NO levels, while increasing SOD and GSH concentrations caused and NO in AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010treated rats as compared to nontreated rats. Conclusively, aqueous or ethanol extracts of\n                    <jats:italic>T. stapfiana<\/jats:italic>\n                    stem bark prevented the oxidative stress and inflammation in brain, which made the brain to be not change after administration of the causative agent of cognitive impairment (CI), AlCl\n                    <jats:sub>3<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/omcl\/5106228","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T05:30:10Z","timestamp":1754631010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Tabernaemontana stapfiana<\/i>\n                    Britten (Apocynaceae) Stem Bark Prevents Alcl\n                    <sub>3<\/sub>\n                    \u2010Induced Cognitive Disability: Antioxidant and Anti\u2010Inflammatory Activities in Wistar Rats"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8860-0126","authenticated-orcid":false,"given":"Mumbi Laurantine","family":"Ngenteh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-2862","authenticated-orcid":false,"given":"Kada Antoine","family":"Sanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3100-6324","authenticated-orcid":false,"given":"Tangu Patience","family":"Neng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8155-9087","authenticated-orcid":false,"given":"Bih Belta Lilian","family":"Fubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8572-6004","authenticated-orcid":false,"given":"Ndifor Rose","family":"Nchang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2290-2007","authenticated-orcid":false,"given":"Kiafon Betrand","family":"Nsah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-1913","authenticated-orcid":false,"given":"Oumar","family":"Mahamat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.132"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.21608\/mjcu.2020.93997"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13530-020-00061-7"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joad.2016.08.028"},{"key":"e_1_2_12_5_2","first-page":"63","article-title":"Aluminum Induced Neurotoxicity: A Review","volume":"9","author":"Shashani L.","year":"2020","journal-title":"Bulletin of Environment, Pharmacology and Life Sciences"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.13189\/app.2024.120413"},{"key":"e_1_2_12_7_2","doi-asserted-by":"crossref","unstructured":"GinestetL. 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