{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:32:58Z","timestamp":1773012778585,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Numerous cellular and animal studies demonstrated the ability of redox\u2010active Mn(III)\n                    <jats:italic>N<\/jats:italic>\n                    \u2010alkyl\u2010 and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010alkoxyalkylpyridyporphyrins (MnPs) to protect normal tissue while suppressing tumor growth. The mechanism primarily involves the modulation of NF\u2010\u043aB and Nrf2 signaling pathways via catalysis of MnP\/H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010driven protein thiol oxidation. Such differential protection\/suppression effects have paved the way of Mn porphyrins (commonly known as mimics of superoxide dismutase) into clinical trials, therefore introducing new line of therapeutics that are affecting cellular redox status\/oxidative stress, rather than specific proteins. The most clinically advanced Mn porphyrin, Mn(III)\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010tetrakis(\n                    <jats:italic>N<\/jats:italic>\n                    \u2010n\u2010butoxyethyl\u20102\u2010pyridyl) porphyrin (MnTnBuOE\u20102\u2010PyP\n                    <jats:sup>5+<\/jats:sup>\n                    , BMX\u2010001) has progressed into five Phase II clinical trials, two of those related to the injuries of central nervous system. Currently, no efficient treatment for chemotherapy\u2010induced neuropathy is available in clinics. We therefore employed BMX\u2010001 to assess its effect on paclitaxel (PTX)\u2010induced neuropathy. Mechanical (Von\u2010Frey filaments) and thermal (hot plate) stimulation, toxicity (body weight), muscular coordination and general physical condition (rotarod) of female CD\u20101 mice were evaluated over 3 weeks with 2\u2009mg\/kg daily dosing and also at clinically relevant dosing of 0.8\u2009mg\/kg given subcutaneously (SC) twice weekly after 1.6\u2009mg\/kg loading dose. Data revealed a significant ability of BMX\u2010001 to suppress peripheral neuropathy and neuroinflammation. Importantly, while protecting peripheral tissue, BMX\u2010001 suppressed the tumor growth of CAOV2 high\u2010grade serous ovarian cancer in a mouse subcutaneous xenograft model. Previously, the strong anticancer effect was only seen when Mn porphyrins were combined with radiation, chemotherapy, and ascorbate (Asc). Our data further demonstrate that high\u2010grade serous ovarian cancer is the first in vivo cancer thus far studied where redox\u2010active Mn porphyrin, as a single agent, exhibits strong anticancer effect, comparable to that of PTX. The effect is presumably due to high tumor levels of BMX\u2010001 and high oxidative stress specific to the aggressive chemoresistant CAOV2 cell line. Such a strong anticancer effect of BMX\u2010001 would allow for lowering the dosing of PTX and reducing the neuropathy. The combined neuropathy protection and anticancer efficacy demonstrate, therefore, strong therapeutic potential of BMX\u2010001 for gynecological cancers. Moreover, the ability of BMX\u2010001 to suppress neuropathy may be relevant for all types of cancer where chemotherapeutics that induce neuropathy are used as a standard\u2010of\u2010care.\n                  <\/jats:p>","DOI":"10.1155\/omcl\/6333148","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T07:19:30Z","timestamp":1756106370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of Paclitaxel\u2010Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE\u20102\u2010PyP\n                    <sup>5+<\/sup>\n                    (BMX\u2010001)"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6246","authenticated-orcid":false,"given":"Ivan","family":"Spasojevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-6700","authenticated-orcid":false,"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-3188","authenticated-orcid":false,"given":"Welida Tamires Alves","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-8398","authenticated-orcid":false,"given":"Weina","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-6234","authenticated-orcid":false,"given":"Li","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8096-2456","authenticated-orcid":false,"given":"Cathleen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-0680","authenticated-orcid":false,"given":"Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2946-8648","authenticated-orcid":false,"given":"Shasha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4527-5861","authenticated-orcid":false,"given":"Hannah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9939-0824","authenticated-orcid":false,"given":"Gaomong","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8612-1676","authenticated-orcid":false,"given":"Artak","family":"Tovmasyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-2940","authenticated-orcid":false,"given":"Huaxin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8037-1861","authenticated-orcid":false,"given":"Ines","family":"Batinic-Haberle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-7662","authenticated-orcid":false,"given":"Angeles Alvarez","family":"Secord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33108"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-022-00294-9"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.626687"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.152"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12544"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7453"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6653790"},{"key":"e_1_2_14_8_2","article-title":"The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP(5+), Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined With Cisplatin","volume":"15","author":"Soares R. 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