{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:04:37Z","timestamp":1792897477245,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    High\u2010intensity interval training (HIIT) is a form of interval exercise that enhances capacity and benefits well\u2010being. Resveratrol is a naturally occurring polyphenol prevalent in grapes and red wine, demonstrating significant health effects on the body. This study sought to evaluate the synergistic effects of swimming HIIT and resveratrol intake on the expression of SIRTs 4, SIRTs 5, and superoxide dismutases (SOD1 and SOD2) in the frontal lobe of elderly rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    Forty\u2010five male Wistar rats, aged 22 months, were categorized into five groups: the control group (CTL), the swimming HIIT group (Ex: Exercise), the swimming HIIT with resveratrol group (R\u2009+\u2009Ex), the resveratrol group (R), and the solvent control group (vehicle). The R\u2009+\u2009Ex group engaged in high\u2010intensity interval swimming and ingested resveratrol (10\u2009mg\/kg\/day via gavage) for 6 weeks. During the initial and final sessions of each week, blood samples from the rats in the Ex and R\u2009+\u2009Ex groups were collected for lactate analysis. The proteins SIRTs 4 and 5, as well as SODs 1 and 2, were quantified using the western blot approach.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Integrating HIIT with resveratrol markedly enhanced the expression of SIRT4, SIRT5, and antioxidant enzymes in the frontal lobe of elderly rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Resveratrol and HIIT, particularly their synergistic effects, provide antioxidant and antiaging benefits on the frontal lobe of aged rats.\n                  <\/jats:p>","DOI":"10.1155\/omcl\/8251896","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:33:57Z","timestamp":1738157637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High\u2010Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-0037","authenticated-orcid":false,"given":"Amin","family":"Mehrabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-3561","authenticated-orcid":false,"given":"Reza","family":"Nuori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-0669","authenticated-orcid":false,"given":"Abbasali","family":"Gaeini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-6557","authenticated-orcid":false,"given":"Maryam","family":"Amirazodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-7805","authenticated-orcid":false,"given":"Mohammad","family":"Mehrtash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-5578","authenticated-orcid":false,"given":"Mohsen Abedini","family":"Esfahlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-5110","authenticated-orcid":false,"given":"Mina","family":"Bahrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-1590","authenticated-orcid":false,"given":"Mohammad Abbas","family":"Bejeshk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6708-1720","authenticated-orcid":false,"given":"Mohammad Amin","family":"Rajizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Ageing","author":"Phillipson C.","year":"2013"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13931"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03687-w"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052825"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13080"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.014"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0225"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030651"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00019-2"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084052"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0441"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05798-8"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.03.013"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2023.102357"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43519-7"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.001"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20641"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7290"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.614331"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2023.11.007"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-417148-0.00005-4"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198566427.003.0008"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700666092"},{"key":"e_1_2_11_24_2","first-page":"628","volume-title":"Principles of Frontal Lobe Function","author":"Cabeza R.","year":"2012"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804281-6.00020-3"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00167"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.42"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.944697"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8638714"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2022.57780.12853"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000534392"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5373117"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5176645"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/0361073X.2020.1754015"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-03907-y"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2022.08.001"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.22038\/AJP.2022.19720"},{"key":"e_1_2_11_38_2","article-title":"Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain, Medical Science Monitor","volume":"24","author":"Shi Z.","year":"2018","journal-title":"International Medical Journal of Experimental and Clinical Research"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6030091"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308601317203567"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0396-8"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.2741\/e863"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23162"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-170035"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/loac025"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.724506"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-017-9685-9"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010728"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-022-09978-7"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-7443-4_14"},{"key":"e_1_2_11_51_2","first-page":"596","article-title":"Synergistic Effects of Quercetin and Regular Exercise on the Recovery of Spatial Memory and Reduction of Parameters of Oxidative Stress in Animal Model of Alzheimer\u2019s Disease","volume":"19","author":"Molaei A.","year":"2020","journal-title":"EXCLI Journal"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20190079"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep24156"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.913240"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101271"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02357-6"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-67202012000100011"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200609000-00014"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061810"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03824-3"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02398-5"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01057.2004"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.073478"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-177295"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.3233\/BPL-160043"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00262"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.13-010.Radak"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.05.012"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.03.015"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.01.004"},{"key":"e_1_2_11_71_2","unstructured":"YokokawaT. SugaT. andKidoK. et al.Chronic Exercise Regulates the Expression of Mitochondrial Sirtuins in Murine Skeletal Muscle 2016."},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2018.1458071"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00032"},{"key":"e_1_2_11_74_2","first-page":"111","article-title":"Resveratrol Reduces Endothelial Oxidative Stress by Modulating the Gene Expression of Superoxide Dismutase 1 (SOD1), Glutathione Peroxidase 1 (GPx1) and NADPH Oxidase Subunit (Nox4)","volume":"60","author":"Spanier G.","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.03.027"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0209"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0366-8"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.04.001"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1947928"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2022.03.001"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.11.012"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.07.005"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.5812\/jamm-144281"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8251896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/omcl\/8251896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8251896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:15:36Z","timestamp":1773008136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/omcl\/8251896"}},"subtitle":[],"editor":[{"given":"Balakrishnan","family":"Rengasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/omcl\/8251896"],"URL":"https:\/\/doi.org\/10.1155\/omcl\/8251896","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8251896"}}