{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:39Z","timestamp":1791614979859,"version":"4.3.4"},"reference-count":122,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"Universit\u00e0 degli Studi di Parma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Reactive oxygen and nitrogen species participate in physiological signaling and adaptation during fetal and neonatal development, whereas excessive, prolonged, or spatially dysregulated production may contribute to oxidative and nitrosative tissue injury. Redox dysregulation has been extensively investigated in neonatal conditions, including bronchopulmonary dysplasia (BPD), hypoxic\u2010ischemic encephalopathy, retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), congenital heart disease (CHD), and hyperbilirubinemia. Its relationship with bone metabolism is well established in adult and pediatric disorders, including osteoporosis, inflammatory bone loss, and iron\u2010overload\u2010related bone disease. However, the potential contribution of perinatal redox imbalance to early skeletal development remains comparatively underexplored. This narrative review critically examines the biochemical mechanisms of reactive species generation, their interaction with inflammatory pathways, and the experimental and clinical evidence linking redox dysregulation to neonatal organ injury. Particular attention is given to the developing skeleton as a potentially underrecognized target. Experimental studies indicate that excessive reactive species can impair chondrogenesis, alter osteoblast and osteoclast activity, disrupt collagen and osteogenic signaling, and interfere with skeletal growth. Human evidence is predominantly observational. Preliminary longitudinal data show inverse associations between cord\u2010blood markers of oxidative DNA and protein modification and REMS\u2010derived skeletal Z\u2010scores during the first year of life. These findings suggest that early redox imbalance may impair bone quality and growth trajectories in newborns. Prospective studies integrating standardized redox biomarkers, bone\u2010metabolism indices, imaging, nutrition, medication exposure, growth, and fracture outcomes are needed to determine whether redox dysregulation independently contributes to impaired skeletal development.<\/jats:p>","DOI":"10.1155\/omcl\/8655644","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:18:40Z","timestamp":1791613120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative Stress in Neonatal Disease: Established Organ Injury and Emerging Evidence for Skeletal Involvement"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4464-9421","authenticated-orcid":false,"given":"Laura","family":"Cannav\u00f2","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit University Hospital of Verona  Piazzale Stefani 1 Verona 37126 Italy  univr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6669-2439","authenticated-orcid":false,"given":"Virginia","family":"Beretta","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Petrolini","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-5613","authenticated-orcid":false,"given":"Vincenzo","family":"Raitano","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2252-0592","authenticated-orcid":false,"given":"Elena","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Dell\u2019Orto","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-3454","authenticated-orcid":false,"given":"Silvia","family":"Carloni","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino Carlo Bo  Urbino Italy  uniurb.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-1475","authenticated-orcid":false,"given":"Maria Cristina","family":"Albertini","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino Carlo Bo  Urbino Italy  uniurb.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-5657","authenticated-orcid":false,"given":"Serafina","family":"Perrone","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Medicine and Surgery University of Parma Pietro Barilla Children\u2019s Hospital  Parma 43126 Italy  unipr.it"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10030579"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075814"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1179\/1351000214Y.0000000111"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101157"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.035"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7483062"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02278-8"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-014-0446-0"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3063"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031841"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC02179G"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22540"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120212"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32916"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1245049"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2013.00232"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-014-0475-8"},{"key":"e_1_2_12_24_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1515\/jpm-2022-0259","article-title":"Oxygenation of the Newborn: The Impact of One Molecule on Newborn Lives","volume":"51","author":"Saugstad O. D.","year":"2022","journal-title":"Journal of Perinatal Medicine"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.04.003"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101083"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1869934"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.030"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102405"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2019.108295"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4782426"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.03.008"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.034"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060656"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3007"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071394"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.652687"},{"key":"e_1_2_12_39_2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/ajcn\/61.5.1067","article-title":"l-Cysteine and Glutathione Metabolism are Impaired in Premature Infants Due to Cystathionase Deficiency","volume":"61","author":"Vi\u00f1a J.","year":"1995","journal-title":"The American Journal of Clinical Nutrition"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199402000-00023"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000901"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.03.008"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.017"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.03.004"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1550765"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212504"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1095-6433(01)00324-5"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-63245-2"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0434"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200309-1282OC"},{"key":"e_1_2_12_51_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-981-13-8413-4_16","volume-title":"Oxidative Stress in Lung Diseases","author":"Perrone S.","year":"2019"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810145"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4766"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2024"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.09.005"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.588229"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13233"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6262"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.01.004"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369373"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199808000-00008"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000082017.97479.39"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02724267"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010037"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2845-0"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.083"},{"key":"e_1_2_12_67_2","volume-title":"StatPearls","author":"Pattnaik P.","year":"2026"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00419-0"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013232.pub2"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.796170"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0461-1"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.5.441"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.11.017"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200208000-00013"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.74"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.618622"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/children9091376"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0639-6"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12658-X"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00088"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7608108"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119660"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2026.3082"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1566-8"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.02.009"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2018.57.03.15"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7836828"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.1"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3940241"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.81.3.395"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.2741\/s33"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054366"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2005.05.004"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.091"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158416"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1159\/000342340"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.663197"},{"key":"e_1_2_12_99_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/1573396317666210426102610","article-title":"New Strategies for Necrotizing Enterocolitis Diagnosis and Prevention in Newborns","volume":"17","author":"Perrone S.","year":"2021","journal-title":"Current Pediatric Reviews"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23349"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb02918.x"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2021.eng.e18"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1710182"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2024.136230"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020299"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.147"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7120193"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2656-9689"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15163515"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01901.x"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702811200"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3662"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102437"},{"key":"e_1_2_12_114_2","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1182\/blood-2009-12-260083","article-title":"Bone Loss Caused by Iron Overload in a Murine Model: Importance of Oxidative","volume":"116","author":"Tsay J.","year":"2010","journal-title":"Blood"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.5.1119"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.233213"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010154"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071694"},{"key":"e_1_2_12_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2790::AID-ART466>3.0.CO;2-X"},{"key":"e_1_2_12_120_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.gpeds.2025.100294","article-title":"Evidence of Association Between Perinatal Oxidative Stress and Bone Development in the First Year of Life: Preliminary Study of a REMS-Derived Indicator","volume":"14","author":"Perrone S.","year":"2025","journal-title":"Global Pediatrics"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpeds.2025.100261"},{"key":"e_1_2_12_122_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.gpeds.2025.100292","article-title":"Early Bone Health: Exploring Relationship Between Oxidative Stress and Skeletal Development in Newborn Infants","volume":"14","author":"Perrone S.","year":"2025","journal-title":"Global Pediatrics"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8655644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/omcl\/8655644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8655644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:18:43Z","timestamp":1791613123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/omcl\/8655644"}},"subtitle":[],"editor":[{"given":"Erika","family":"Ramos-Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":122,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/omcl\/8655644"],"URL":"https:\/\/doi.org\/10.1155\/omcl\/8655644","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8655644"}}