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Ferulic acid (FA) is a plant phenolic substance with antioxidant, anti\u2010inflammatory, and neuroprotective effects that is used in the treatment of neurodegenerative diseases in traditional medicine. This study evaluated the effect of FA (20 or 80\u2009mg\/kg) alone and then FA (20\u2009mg\/kg) combined with valproate (VPA) or carbamazepine (CBZ) on maximal electroshock\u2010induced seizures (MESs) in mice associated with interleukin\u20101\u03b2 (IL\u20101\u03b2) concentrations and total antioxidant capacity (TAC) assessment in the hippocampus. Male NMRI mice (weight 25\u201330\u2009g) were injected intraperitoneally with saline (1\u2009mL\/kg), FA (20 or 80\u2009mg\/kg), diazepam (D) (20\u2009mg\/kg), VPA (200\u2009mg\/kg), CBZ (10\u2009mg\/kg), FA (20\u2009mg\/kg)\u2009+\u2009VPA (200\u2009mg\/kg), and FA (20\u2009mg\/kg)\u2009+\u2009CBZ (10\u2009mg\/kg) before application of MES. Duration of tonic hind limb extension (HLE), and chimney climbing time and grip\u2010strength were also recorded. Then, mice scarified and hippocampus removed and homogenized. The level of IL\u20101\u03b2 and TAC were determined. FA (20 and 80\u2009mg\/kg) significantly reduced the HLE duration and prevented seizure\u2010induced hippocampal IL\u20101\u03b2 increase and antioxidant capacity decrease. In addition, FA (20\u2009mg\/kg) enhanced the anticonvulsant efficacy of VPA and CBZ by regulating hippocampal IL\u20101\u03b2 and antioxidant capacity. The finding suggest that FA possessed anticonvulsant effect and improved VPA and CBZ efficacy by regulating of IL\u20101\u03b2 and antioxidant capacity in the hippocampus.<\/jats:p>","DOI":"10.1155\/omcl\/8832818","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:19:08Z","timestamp":1760098748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ferulic Acid Attenuates Seizure Severity and Enhances Valproate and Carbamazepine Seizure Preventing Efficacy by Regulating Hippocampal Interleukin\u20101\u03b2 Level and Antioxidant Capacity in 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