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Several studies have demonstrated that the prolongate use of EFV can lead to the development of neurological diseases, such as panic syndrome, depression, and anxiety disorders. In this current study, we evaluate whether the ascorbic acid (AA) treatment can prevent anxiety\u2010like behavior and brain oxidative stress induced by EFV treatment in zebrafish. Our data demonstrated that the EFV treatment induces anxiogenic\u2010like behavior and intense lipid peroxidation in the zebrafish brain. The AA treatment was able to prevent both anxiogenic\u2010like behavior and brain oxidative stress elicited by the EFV treatment. Therefore, our data provide robust evidence that the EFV induced anxiety\u2010like behavior in zebrafish via a redox\u2010dependent pathway and that AA treatment can minimize these adverse effects. 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