{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:32:56Z","timestamp":1773012776130,"version":"3.50.1"},"reference-count":94,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/13\/56\/2020NCD-III"],"award-info":[{"award-number":["5\/13\/56\/2020NCD-III"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/000140"],"award-info":[{"award-number":["ECR\/2016\/000140"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The present study reports the protective effect conferred by scavenging mitochondrial oxidative stress (mtOS) in 5\u2010fluorouracil (5\u2010FU)\u2010induced renal injury.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    5\u2010FU renal toxicity model was created by administering 5\u2010FU (12\u2009mg\/kg b.w. intraperitoneally [i.p.], for 4 days) to male BALB\/c mice. The protective effect of mitochondria\u2010targeted antioxidant (MTA), Mito\u2010TEMPO coadministered at a dosage of 0.1\u2009mg\/kg b.w. i.p., was established in terms of levels\/expressions of renal injury markers, histopathological alterations, oxidative DNA damage, proinflammatory markers, mtOS, mitochondrial dysfunction, and modulation of apoptotic proteins and apoptotic cell death.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A significant rise in the levels of serum urea, uric acid, and creatinine was noted after 5\u2010FU administration to the animals. Immunohistochemical and ELISA findings demonstrated significant decrease in podocin and conversely a significant increase in neutrophil gelatinase\u2010associated lipocalin (NGAL) expression after 5\u2010FU challenge. The histopathological analysis further revealed Bowman\u2019s capsule dilation, glomerular condensation, and vacuolar degeneration. Mito\u2010TEMPO treatment significantly lowered renal injury markers, reversed the expressions of podocin and NGAL to normal, and restored normal histoarchitecture of renal tissue. Mitochondrial reactive oxygen species (mtROS), mtLPO, activity of mitochondrial enzyme complexes, and mitochondrial antioxidant defense status were significantly improved in Mito\u2010TEMPO protected group as compared to the 5\u2010FU group. Further, significantly decreased expression of 8\u2010OHdG, reduction in apoptotic cell death, and modulation of apoptotic proteins Bax, Bcl\u20102, and caspase\u20103 were noted in Mito\u2010TEMPO protected group, indicating its protective effect against 5\u2010FU\u2010induced renal injury.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The approach of targeting mtOS using MTA, Mito\u2010TEMPO, may prove as safe adjuvant in alleviating renal toxicity during 5\u2010FU chemotherapy.\n                  <\/jats:p>","DOI":"10.1155\/omcl\/8892026","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:06:09Z","timestamp":1741741569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeted Modulation of Mitochondrial Oxidative Stress Ameliorates 5\u2010Fluorouracil\u2010Induced Renal Injury in BALB\/c Mice"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-3030","authenticated-orcid":false,"given":"Prasad Kisan","family":"Tambe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-4363","authenticated-orcid":false,"given":"Maya P.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-2858","authenticated-orcid":false,"given":"Komal","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-2632","authenticated-orcid":false,"given":"Sanjay","family":"Bharati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115902"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_2_10_3_2","first-page":"145","article-title":"BY 5-FLUOROURACIL IN RATS","volume":"69","year":"2023","journal-title":"Assiut Veterinary Medical Journal"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12735-y"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.09.015"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.720620"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910537"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2017.01.012"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051005"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43188-023-00204-1"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.21608\/ejz.2019.17844.1014"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10886"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2018.1456548"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2023.05.021"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.01.026"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0677-8"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000489210"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110794"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091329"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00428-x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.05.028"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2006"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-5881-9"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05213.x"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2021.01.003"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2014.942809"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01261-6"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-023-04529-4"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05627.x"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03101-0"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29495"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.11.013"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5828120"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2331-8"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043739"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116211"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.03.001"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.037"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0187-9"},{"key":"e_1_2_10_40_2","volume-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","author":"Suvarna K. S.","year":"2019"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.11.003"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115618247"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.04.047"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93963-3"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/11.1.102"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748233712446728"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.98.3.1098"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002449900510"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00056-8"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2018.07.001"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111285"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.4103\/JCRP.JCRP_10_19"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121523"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.706861"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicines4040078"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2023.2290196"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph16091212"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1612348"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.801837"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00667-7"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu6072619"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100569"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.71.e114441"},{"key":"e_1_2_10_66_2","first-page":"4151","article-title":"Management of Nephrotoxicity of Chemotherapy and Targeted Agents: 2020","volume":"10","author":"Chiruvella V.","year":"2020","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.66.s1.82"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2017.0037"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001170"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-84704-6"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310004409"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.027"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00112.x"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6665"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00513.2006"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9060472"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2743"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.09.007"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-9411-3"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.036"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.07.002"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1080\/10590500902885684"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja077102a"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0695"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081144"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031776"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02508-9"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-42139-1_1"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4905"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.04.001"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0507-487"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.03.016"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-272997"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00285.2020"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8892026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/omcl\/8892026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/omcl\/8892026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:15:55Z","timestamp":1773008155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/omcl\/8892026"}},"subtitle":[],"editor":[{"given":"Sandra","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/omcl\/8892026"],"URL":"https:\/\/doi.org\/10.1155\/omcl\/8892026","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8892026"}}