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A growing body of evidence indicates that altered MUFA metabolism promotes tumour growth while protecting cancer cells from ferroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review summarises current knowledge on the contributions of MUFA metabolism to carcinogenesis, regulation of ferroptosis and treatment response across different cancers. Further, we discussed the emerging treatment strategies targeting MUFA metabolic pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant experimental and clinical studies investigating MUFA metabolism, lipid metabolic reprogramming, ferroptosis and therapeutic interventions in cancer were comprehensively reviewed and critically analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Enhanced de novo MUFA synthesis and incorporation into membrane phospholipids increase the MUFA\u2010to\u2010polyunsaturated fatty acid (PUFA) ratio, thereby reducing the availability of oxidation\u2010prone PUFAs, limiting lipid peroxidation, and protecting cancer cells from ferroptosis. MUFA\u2010driven membrane remodelling enhances membrane fluidity and activates oncogenic signalling pathways, including epithelial\u2010mesenchymal transition (EMT), cancer cell migration, invasion and metastasis. These effects are mediated by the dysregulated expression of key lipogenic enzymes and signalling pathways that reprogramme lipid metabolism to meet the metabolic demands of cancer cells. Multiple studies have shown that MUFA metabolism is a promising therapeutic target. Furthermore, the inhibition of stearoyl\u2010CoA desaturase\u20101 (SCD1) and fatty acid synthase (FASN), key enzymes in MUFA metabolism, sensitises cancer cells to ferroptosis by enhancing lipid peroxidation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MUFA metabolism is a key regulator of cancer progression and ferroptosis resistance. Targeting MUFA metabolic pathways is a promising therapeutic strategy. However, mechanistic studies are required to elucidate the molecular mechanisms underlying sensitivity to ferroptosis and to optimise clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/omcl\/9604592","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:57:24Z","timestamp":1791881844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Lipid Line of Defence: Monounsaturated Fatty Acids (MUFAs) in Cancer and Ferroptosis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Sneha D.","family":"Baadkar","sequence":"first","affiliation":[{"name":"Department of Public Health Genomics Manipal School of Life Sciences Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2017-8664","authenticated-orcid":false,"given":"Amoolya","family":"Kandettu","sequence":"additional","affiliation":[{"name":"Department of Public Health Genomics Manipal School of Life Sciences Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-7706","authenticated-orcid":false,"given":"Swagat","family":"Ray","sequence":"additional","affiliation":[{"name":"School of Natural Sciences College of Health and Science University of Lincoln  Lincoln LN6 7TS UK  lincoln.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-8098","authenticated-orcid":false,"given":"Sanjiban","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Public Health Genomics Manipal School of Life Sciences Manipal Academy of Higher Education  Manipal India  manipal.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.27"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01498-2"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-21-1069"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129921"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0451-4"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215484"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.577420"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020690"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.11.016"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5904-x"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.039"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800049-JLR200"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20200067"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114114"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01624-y"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00702-z"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12161"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.312617"},{"key":"e_1_2_16_20_2","volume-title":"Endotext","author":"Feingold K. 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