{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:49:23Z","timestamp":1772992163780,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Hallucinations and delusions are severe long\u2010term complications of Parkinson\u2019s disease (PD). Clozapine is the only antipsychotic with proven efficacy in PD psychosis (PDPsy) available outside the United States but apprehensions about its adverse event profile result in a substantial underuse of clozapine.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    To investigate the practical use and long\u2010term efficacy of clozapine in severe psychotic disorders in PD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    In this retrospective study, the author used data collected over a period of 20\u2009years and included all PD patients under his care, who were treated with clozapine for psychotic disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    During the observation period, 41 PD patients (38 with PDPsy, 2 with psychotic depression, and one with schizoaffective disorder) were started on clozapine. They had responded poorly or only transiently to quetiapine. An overnight switch to clozapine was tolerated in most. Maximum clozapine doses ranged from 12.5 to 150\u2009mg (72.9\u2009\u00b1\u200929.9\u2009mg). A significant reduction in psychotic symptoms was achieved in 2\u2009days to 6\u2009months. Among the cases tolerating clozapine, 10 had a full, 25 had a good, 3 had a moderate, and 2 had a poor clinical response to clozapine. Treatment lasted up to 12\u2009years. The long\u2010term response was full or good in 23, moderate in 3, and poor in 2 patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Clozapine is often effective in the treatment of psychotic disorders in PD including PDPsy poorly or only transiently responding to quetiapine. Side effects including agranulocytosis are manageable in the majority of cases. Clozapine treatment should not be delayed if other measures against PDPsy prove ineffective.\n                  <\/jats:p>","DOI":"10.1155\/padi\/1068722","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:55:05Z","timestamp":1741694105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clozapine for Quetiapine\u2010Refractory Psychosis in Parkinson\u2019s Disease: A Long\u2010Term Single\u2010Center Retrospective 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