{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:37:46Z","timestamp":1791999466243,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Research into alternative treatments for Parkinson\u2019s disease (PD) is gaining increasing attention.\n                    <jats:italic>Mucuna pruriens<\/jats:italic>\n                    (\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    ), a plant traditionally used in Ayurvedic medicine, contains a significant amount of L\u2010dopa (4%\u20136%), the primary active component of conventional levodopa (LD) therapy\u2014the gold standard treatment for PD.\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    is also recognized for its anti\u2010inflammatory, antioxidant, antiapoptotic, and antiparkinsonian properties, which collectively suggest therapeutic benefits for individuals with PD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This systematic review aims to investigate the efficacy and safety of\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    in managing symptoms of PD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A comprehensive search was conducted in PubMed, Embase, and Web of Science for clinical trials published up to February 2024. Studies comparing\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    to LD were included. Quality assessment was performed, and findings were synthesized narratively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Out of 466 articles identified, 5 clinical trials involving a total of 108 participants (mean age: 60\u2009years) were included. Quality assessment rated one study as high quality, one as having some concerns, and three as low quality. Despite heterogeneity in\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    interventions, the findings consistently showed improvements in PD symptoms and therapy\u2010related complications. Treatment with\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    was associated with a shorter time to reach the \u201con\u201d disease stage, prolonged duration of this stage, and fewer adverse events, with no dyskinesia reported.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    <jats:italic>M. pruriens<\/jats:italic>\n                    shows promise in improving motor symptoms and reducing therapy complications in PD patients. However, current clinical evidence is limited, and further high\u2010quality trials are needed to confirm its efficacy and safety.\n                  <\/jats:p>","DOI":"10.1155\/padi\/1319419","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:04:38Z","timestamp":1755511478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Mucuna pruriens<\/i>\n                    Treatment for Parkinson Disease: A Systematic Review of Clinical 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