{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:49:22Z","timestamp":1772992162925,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Parkinson\u2019s disease (PD) is a chronic, neurodegenerative disease of the central nervous system (CNS). Complications in PD are related to impaired cardiorespiratory capacity, and the presence of motor and nonmotor symptoms, such as reduced cardiorespiratory fitness, decreased respiratory muscle strength and lung volumes and capacities, bradykinesia, muscle rigidity, attenuation of strength and lower limb muscle power, sleep disorders, anxiety, and depressive symptoms. The practice of high\u2010intensity exercise and the examination of the aquatic environment may help to minimize these symptoms and slow disease progression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To develop a water physical exercise program (WPEP) focusing on high\u2010intensity interval training (HIIT) for individuals with DP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This is a protocol for a single blinded controlled clinical trial. The sample will consist of individuals with PD between Stages 1 and 4 on the Hoehn and Yahr (HY) Scale, divided into a control group and a WPEP group (which will participate in the WPEP). The outcomes will be divided into three categories: cardiorespiratory, motor, and nonmotor aspects. The WPEP will last 12\u2009weeks, and the intervention will take place two times a week, with a duration of approximately 35\u2009min, with an interval between 48 and 72\u2009h between training sessions for muscle recovery, for a total of 24 sessions. It is expected that this study will establish parameters for prescribing and monitoring a WPEP for individuals with PD Stages 1\u20134 on the HY scale, enhancing the practice of exercise prescription.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Brazilian Register of Clinical Trials: RBR\u20103hp5yvh\n                  <\/jats:p>","DOI":"10.1155\/padi\/1946207","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:20:09Z","timestamp":1743751209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Water Physical Exercise Program (WPEP) Using High\u2010Intensity Interval Training in Individuals With Parkinson\u2019s Disease: A Clinical Trial Protocol"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-7830","authenticated-orcid":false,"given":"Lu\u00eds Henrique","family":"Paladini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Cristina Leveck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tain\u00e1","family":"Christinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Siega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-0624","authenticated-orcid":false,"given":"Andr\u00e9 Eduardo Falcoski","family":"Doliny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Cesar Barauce","family":"Bento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia","family":"Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-020-0117-1"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0099-z"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.62"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25799"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202100"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2018-0588"},{"key":"e_1_2_9_8_2","volume-title":"Guidelines on Physical Activity and Sedentary Behaviour: At a Glance","author":"WHO","year":"2020"},{"key":"e_1_2_9_9_2","first-page":"384","article-title":"Is Objectively Assessed Sedentary Behavior","volume":"388","author":"Engeroff T.","year":"2018","journal-title":"Physical Activity and Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age? 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