{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:49:22Z","timestamp":1772992162372,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["RG13793-35"],"award-info":[{"award-number":["RG13793-35"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2032s disease (PD) is an age\u2010related neurodegenerative condition with a range of motor and nonmotor symptoms. Nonmotor symptoms such as constipation and orthostatic hypotension can occur at any stage, while dysphagia is common in later stages of the disease. Previous work by our group showed that people with PD who lose weight within a year of diagnosis had a poorer prognosis. In this study, we explored whether fluid intake was also reduced in people with newly diagnosed PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We invited people with newly diagnosed PD (within 6\u2009months of a diagnosis or longer if not requiring treatment) to join the study. Controls were household members of the participants with PD. Participants all underwent the same assessments, including a 24\u2010h dietary recall, a video\u2010recorded swallowing assessment, and grading of stool sample consistency using the Bristol Stool Chart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We recruited 30 participants, 19 with PD and 11 household controls. People living with PD reported significantly lower fluid intake from drinks (control median\u2009=\u20091799\u2009mL, PD median\u2009=\u20091124\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005 for difference in medians). People with PD drank fluid slightly slower than the controls, 6.0\u2009mL\/second vs 7.5\u2009mL\/second, but this did not reach statistical significance. Participants with PD had significantly harder stools than controls, with a mean Bristol Stool Chart number of 3.2 vs 4.6 for controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PD is associated with significantly reduced intake of fluids from beverages around the time of diagnosis, which may contribute to constipation and orthostatic hypotension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/padi\/2440967","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:24:26Z","timestamp":1760005466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daily Fluid Intake in People With Newly Diagnosed Parkinson\u2019s Disease Is Reduced Compared With Controls"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-9743","authenticated-orcid":false,"given":"Isobel J.","family":"Sleeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus D.","family":"MacLeod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Tarr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collette","family":"McGhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Fyfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2325-3380","authenticated-orcid":false,"given":"Carrie","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-0013","authenticated-orcid":false,"given":"Karen","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyo Kyaw","family":"Myint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M.","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"World Health Organisation Parkinson\u2019s disease: A Public Health Approach 2022."},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.06.007"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13919"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22226"},{"key":"e_1_2_10_5_2","unstructured":"SingaramC. GaumnitzE. A. AshrafW. MM. andQuigleyE. Dopaminergic Defect of Enteric Nervous System in Parkinson\u2019s disease Patients With Chronic Constipation."},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21625"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.128556"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.11.006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13713"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2010.1459"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112609"}],"container-title":["Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/padi\/2440967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/padi\/2440967","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/padi\/2440967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:43:51Z","timestamp":1772977431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/padi\/2440967"}},"subtitle":[],"editor":[{"given":"Cristine","family":"Alves da Costa","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/padi\/2440967"],"URL":"https:\/\/doi.org\/10.1155\/padi\/2440967","archive":["Portico"],"relation":{},"ISSN":["2090-8083","2042-0080"],"issn-type":[{"value":"2090-8083","type":"print"},{"value":"2042-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2440967"}}