{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:57:34Z","timestamp":1781690254527,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1A02086175"],"award-info":[{"award-number":["2018R1D1A1A02086175"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022M3A9B6017813"],"award-info":[{"award-number":["NRF-2022M3A9B6017813"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is increasing demand for an effective adjuvant therapies for Parkinson\u2019s disease (PD) patients to minimize side effects and improve quality of life, due to unmet needs not fully addressed by conventional treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the long\u2010term effects of adjuvant acupuncture\u2010related therapies on medication use and mortality in patients with PD using the National Health Insurance Service (NHIS) database in Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NHIS records from 2010 to 2011 were searched to extract the study population. The medical records of patients with PD were followed from the initial diagnosis to August 2018. Propensity score matching was performed using covariates, including age group, sex, and duration of levodopa therapy. Odds ratios (ORs) of levodopa therapy and nonmotor symptom medication use were examined. Cox proportional hazards modeling and Kaplan\u2013Meier analysis were performed to determine differences between acupuncture\u2010related therapy users (ACU group) and nonusers (non\u2010ACU group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ACU group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923,454) used less levodopa therapy compared to non\u2010ACU group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923,454) but showed higher use of nonmotor symptom medications including those for sleep disorders, anxiety, and depression. In the Cox proportional hazards model, the ACU group was associated with a slightly lower long\u2010term risk of all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture\u2010related therapies\u2014defined here as one or more treatments delivered at Korean medicine clinics, including acupuncture, electroacupuncture, moxibustion, cupping, and herbal formulations\u2014were more frequently received by patients with nonmotor symptoms. The use of levodopa therapy and all\u2010cause mortality was lower in the ACU group than in the non\u2010ACU group. Given the observational design, heterogeneity of the exposure, and potential residual confounding, these associations should not be interpreted as causal evidence of therapeutic benefit. Prospective, randomized, sham\u2010controlled trials are required to determine whether acupuncture\u2010related therapies confer specific clinical benefit in patients with PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/padi\/5512318","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:32:09Z","timestamp":1781688729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture\u2010Related Therapies as a Potential Adjuvant Option for Parkinson\u2019s Disease: Effects on Symptom Management, Medication Use, and Mortality"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-5401","authenticated-orcid":false,"given":"Ye-Seul","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-5638","authenticated-orcid":false,"given":"Han-Gyul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-2664","authenticated-orcid":false,"given":"Hi-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-3515","authenticated-orcid":false,"given":"Seungwon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2141-3483","authenticated-orcid":false,"given":"Bo-Hyoung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030551"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2016.06.012"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(03)00568-3"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.25"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07458.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00019-8"},{"key":"e_1_2_10_9_2","article-title":"Kim Hee-Tae Current Status and Future of Parkinson\u2019s Disease in Korea","volume":"11","author":"Kim J.-S. 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