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Ferroptosis is a mechanism mediating OS\u2010induced damage, with growing evidence of specific involvement in both Parkinson\u2019s disease (PD) and ischemic stroke. Regular physical activity may have an antioxidant effect by increasing the production and activity of nonenzymatic and enzymatic antioxidants. Among the biological mediators of physical activity, irisin may act as an agent capable of inducing systemic changes and crossing the brain\u2010blood barrier. 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