{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:03:56Z","timestamp":1784786636186,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease is a progressive neurodegenerative disorder with no currently approved disease\u2010modifying therapies. Alpha\u2010synuclein targeting monoclonal antibodies provide a potential therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate published studies of the efficacy and\/or safety of monoclonal antibodies that target alpha\u2010synuclein in human subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of peer\u2010reviewed journal articles was conducted. PubMed, Embase and Scopus were searched up to March 2, 2025. Results were synthesised narratively. Risk of bias was assessed, and sensitivity analysis excluding studies with high risk was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After screening 1509 papers, 10 publications incorporating a total of 13 studies were included. These assessed Prasinezumab, Cinpanemab, Exidavnemab and Lu\u2010AF82422 with heterogeneity amongst studies. Tolerability was generally favourable across all studies. Cinpanemab showed almost no efficacy, whilst Prasinezumab demonstrated mixed motor symptom improvements. Safety profiles for all monoclonal antibodies reflected mostly consistent rates of adverse events. Six studies were removed in the sensitivity analysis due to high risks of bias, which reduced Prasinezumab\u2019s apparent efficacy findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The efficacy of monoclonal antibodies in Parkinson\u2019s disease remains uncertain with most positive results coming from the studies with high risks of bias. Prasinezumab demonstrated an efficacy profile with the potential of significance, warranting further research. This lack of efficacy reported with Cinpanemab is consistent with the manufacturer\u2019s decision to discontinue it. Safety data on Exidavnemab and Lu\u2010AF82422 in healthy volunteers support further investigation in Parkinson\u2019s disease patients. Future trials may benefit from the inclusion of subjects at earlier disease stages, diagnosed before clinical features have emerged.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT03100149\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/padi\/8540084","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:27:47Z","timestamp":1784784467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy and Safety of Monoclonal Antibodies That Target Alpha\u2010Synuclein in Parkinson\u2019s Disease: A Systematic Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4569-6189","authenticated-orcid":false,"given":"Daniel","family":"Coles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2373-0333","authenticated-orcid":false,"given":"Anish","family":"Kalyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5350-0491","authenticated-orcid":false,"given":"Sameer","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8310-6575","authenticated-orcid":false,"given":"Dhyana","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7471-9921","authenticated-orcid":false,"given":"Thiara","family":"Rupasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9559-8798","authenticated-orcid":false,"given":"Charlie","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-2160","authenticated-orcid":false,"given":"Amit","family":"Batla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-070X","authenticated-orcid":false,"given":"Tim","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25945"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8940-21"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology9050103"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crbeha.2021.100049"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322338"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2024.105760"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170510143821"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-240272"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2024.100163"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61983"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202867"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03270-6"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02886-y"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2203395"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209137"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)02034-5"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2401857"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27738"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26878"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1487"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib11010017"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.6103"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29784"},{"key":"e_1_2_11_27_2","unstructured":"MeglioM. 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