{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:06:49Z","timestamp":1779797209924,"version":"3.53.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease (PD) is a prevalent neurodegenerative disease, whereas nonalcoholic fatty liver disease (NAFLD) is a common metabolic liver disorder. Growing evidence suggests that NAFLD may affect the central nervous system through the liver\u2013brain axis, potentially contributing to PD, although the underlying molecular mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify differentially expressed genes (DEGs), transcriptomic data for NAFLD and PD were sourced from the GEO database. Key common candidate genes were screened using protein\u2013protein interaction (PPI) networks, machine learning approaches (LASSO, neural networks, and random forest), and functional enrichment analyses, including GO, KEGG, GSEA, and GSVA. Immune infiltration, TF\u2010miRNA regulatory networks, and single\u2010cell RNA sequencing analyses were applied to investigate gene function, immune regulation, and cellular distribution. Candidate drugs were predicted using bioinformatic approaches and validated through molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CASP1, CCNA2, and INHBE were identified as three core common candidate genes that may be associated with NAFLD and PD. Involvement of these genes includes inflammatory responses, regulation of the cell cycle, metabolic pathways, and immune microenvironment remodeling. The analysis of the TF\u2010miRNA network suggested possible regulation by transcription factors CEBPB, BRD4, FOS, and miRNAs such as hsa\u2010miR\u201029b\u20101\u20105p and hsa\u2010miR\u2010128\u20103p. Drug prediction and molecular docking identified ethinyl estradiol, mesalamine, and seliciclib as candidate therapeutics, showing strong binding affinity to the core targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study offers a comprehensive elucidation of the molecular ties between NAFLD and PD. The identified core genes and candidate drugs offer theoretical support for potential candidate biomarkers and therapeutic targets in comorbid NAFLD and PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/padi\/8731032","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:43:31Z","timestamp":1779795811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Gene Signatures and Molecular Mechanisms for Diagnosing Parkinson\u2019s Disease and Nonalcoholic Fatty Liver Disease Using Machine 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