{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:58:30Z","timestamp":1782403110226,"version":"3.54.5"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Diabetes"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Myokines are secreted by skeletal muscle and play a role in their metabolic function and crosstalk with various tissues. Myokines appear to be involved in the pathogenesis of obesity and type 2 diabetes (T2D), yet little is known regarding their function in type 1 diabetes (T1D).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To assess the levels and clinical correlates of a panel of five myokines, comparing adolescents with recent\u2010onset T1D, prolonged disease, and healthy controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Fifty\u2010eight adolescents participated; 20 with recent\u2010onset T1D, 20 with over 7 years of T1D, and 18 healthy controls were included. Clinical and laboratory data were collected, including levels of Apelin, Irisin, Interleukin\u20106 (IL\u20106), Fibroblast growth factor 21 (FGF21), and Myostatin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Apelin levels were lower in patients with prolonged T1D compared with patients with recent\u2010onset T1D and controls, (117.9\u2009\u00b1\u200994.3, 228.3\u2009\u00b1\u2009181.6, and 224.4\u2009\u00b1\u2009138.4\u2009pg\/ml, respectively; analysis of variance (ANOVA)\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029). Other myokines did not differ significantly between groups. Apelin levels correlated with fasting C\u2010peptide levels (\n                    <jats:italic>r\u2009=<\/jats:italic>\n                    \u20090.337,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.010). In patients with prolonged T1D, myostatin positively correlated with insulin doses (total daily dose\n                    <jats:italic>r\u2009=<\/jats:italic>\n                    \u20090.590,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.006 and basal daily dose\n                    <jats:italic>r\u2009=<\/jats:italic>\n                    \u20090.645,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). Both apelin and myostatin levels negatively correlated with the diastolic blood pressure (BP) percentile (\n                    <jats:italic>r\u2009=<\/jats:italic>\n                    \u2009\u2212 0.324,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013;\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2212 0.302,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.024, respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Our results demonstrate lower levels of apelin, a myokine related to the beneficial metabolic effects of skeletal muscle, in prolonged T1D. The correlations of apelin with C\u2010peptide and myostatin with insulin doses may reflect a relationship with beta\u2010cell function and insulin sensitivity.\n                  <\/jats:p>","DOI":"10.1155\/pedi\/1578938","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T10:09:35Z","timestamp":1744106975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Apelin and Myostatin Levels in Adolescents With Type\u20101\u2010Diabetes"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-7624","authenticated-orcid":false,"given":"Michal","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8416-5341","authenticated-orcid":false,"given":"Lotem","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Shehadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogher","family":"Khamaisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026070911202"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M110.002113"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00720"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa016"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094636"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1404"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/11795514221074679"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13055"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32495"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-176917"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100057"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0994-y"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182178bb4"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2010.00699.x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01062-y"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234914"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-017-0979-9"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112060"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1977.tb05654.x"},{"key":"e_1_2_10_20_2","first-page":"73","article-title":"Diffuse Muscle Fiber Atrophy in Newly Diagnosed Diabetes","volume":"5","author":"Jakobsen J.","year":"1986","journal-title":"Clinical Neuropathology"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2005.00120.x"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1025765"},{"key":"e_1_2_10_23_2","doi-asserted-by":"crossref","unstructured":"MaratovaK. SoucekO. andMatyskovaJ. et al.Muscle Functions and Bone Strength Are Impaired in Adolescents With Type 1 Diabetes Bone 2018 106 Bone. 22\u201327.","DOI":"10.1016\/j.bone.2017.10.005"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13237"},{"key":"e_1_2_10_25_2","unstructured":"CDC Growth Charts: United States Centers for Disease Control and Prevention National Center for Health Statistics 2000."},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.158"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.820002"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00772-y"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025710"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00490.2007"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1427"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1084-x"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.03.006"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1631"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.144"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1376"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12404"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S189264"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2010.081"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2017.204"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8379294"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404149200"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01821-1"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000241"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0131-6"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2018-0070"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1635622"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098195"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1628067"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111888"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.10.020"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.endinu.2023.04.002"},{"key":"e_1_2_10_53_2","first-page":"1196","article-title":"Effect of Aerobic Exercise on Serum Concentration of Apelin, TNF\u03b1 and Insulin in Obese Women","volume":"15","author":"Sheibani S.","year":"2012","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2022.11.003"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/387083a0"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00107.2003"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0915"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14500"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-021-00317-y"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0512"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000493"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr024"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00782.2020"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1515\/folmed-2017-0066"}],"container-title":["Pediatric Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/pedi\/1578938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/pedi\/1578938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/pedi\/1578938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:12:00Z","timestamp":1772957520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/pedi\/1578938"}},"subtitle":[],"editor":[{"given":"Rasha","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/pedi\/1578938"],"URL":"https:\/\/doi.org\/10.1155\/pedi\/1578938","archive":["Portico"],"relation":{},"ISSN":["1399-543X","1399-5448"],"issn-type":[{"value":"1399-543X","type":"print"},{"value":"1399-5448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1578938"}}