{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:46:48Z","timestamp":1772981208604,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00436"],"award-info":[{"award-number":["PI18\/00436"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00045"],"award-info":[{"award-number":["PI22\/00045"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Diabetes"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    This study aimed to identify age\u2010related peripheral immune endotypes in pediatric patients with type 1 diabetes (T1D) at disease onset and assess their metabolic control 1 year post\u2010diagnosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Immune cell subpopulations (T and B lymphocytes, myeloid cells, and natural killer [NK] cells) were analyzed via multicolor flow cytometry in pediatric T1D patients and age\u2010 and sex\u2010matched controls, grouped as &lt;7 years, 7\u201312 years, and &gt;12 years. Sociodemographic, clinical, and metabolic data were collected, including autoantibodies, bicarbonate (HCO\n                    <jats:sub>3<\/jats:sub>\n                    ), C\u2010peptide, HbA1c, and time in range (TIR), with follow\u2010up for 1 year to evaluate partial remission (PR) likelihood and metabolic control.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Patients &lt;7 years showed reduced regulatory immune cells (memory\/activated regulatory T lymphocytes (Tregs), regulatory B cells, and Th17) and more severe disease onset (shorter symptoms, greater acidosis, and lower C\u2010peptide). Ages 7\u201312 exhibited increased memory B cells, particularly the unswitched ones. Myeloid cells showed no significant variation in T1D, despite age trends in controls. Anti\u2010insulinoma\u2010antigen 2 (IA2) titers were lower in patients &gt;12 years, while anti\u2010glutamic acid decarboxylase 65 (GAD65) positivity remained constant. Younger patients had lower PR rates and poorer glycemic control at 1 year.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Younger patients face greater immune dysregulation and \u03b2\u2010cell loss, while older patients show better immune maturity and metabolic outcomes. These differences underline the need for age\u2010specific T1D therapies.\n                  <\/jats:p>","DOI":"10.1155\/pedi\/5512196","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:03:57Z","timestamp":1758963837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Peripheral Blood Endotypes Associated With Age in Pediatric Type 1 Diabetes"],"prefix":"10.1155","volume":"2025","author":[{"given":"Laia","family":"Gomez-Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-818X","authenticated-orcid":false,"given":"David","family":"Perna-Barrull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Sol","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Valls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Castiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-0779","authenticated-orcid":false,"given":"Marta","family":"Vives-Pi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-2982","authenticated-orcid":false,"given":"Marta","family":"Murillo-Vall\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.16"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0880"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1083-4"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2523-3"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3514-y"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05115-6"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00853-0"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1615"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0097"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.10.005"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16327-0"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4067-4"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0365"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101591"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05114-7"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904452"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc8980"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0238"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1987"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825426"},{"key":"e_1_2_13_21_2","doi-asserted-by":"crossref","unstructured":"G\u00f3mez Mu\u00f1ozL. 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