{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:46:36Z","timestamp":1772981196465,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Diabetes"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) disproportionately affects females with type 1 diabetes (T1D), yet the emergence of sex\u2010specific metabolic risk during early disease remains unclear. We evaluated whether sex differences in BMI percentile (BMIp) and LDL\u2010cholesterol (LDL\u2010C) trajectories appear within the first 2 years following T1D diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 542 youth with new\u2010onset T1D (mean age 10.4\u2009\u00b1\u20093.9 years; 54.1% male) and assessed sex differences in BMIp and LDL\u2010C trajectories using linear mixed\u2010effects models, adjusting for age, HBA1c and diabetic ketoacidosis (DKA) status at diagnosis, and baseline weight category (LDL\u2010C model only).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At diagnosis, median BMIp did not differ by sex (females: 50.9 [IQR: 19.2\u201384.1] vs. males: 63.0 [17.8\u201393.0];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.15). Over 2 years, females experienced significantly greater BMIp increases (median change: 27.4 [5.1, 49.7] vs. 13.1 [\u20134.3, 30.5] percentage points;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). Adjusted models confirmed steeper increases in BMIp for females compared to males (sex\u2009\u00d7\u2009time interaction: 7.54 [3.13, 11.94];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001). LDL\u2010C was higher in females at diagnosis (2.51\u2009\u00b1\u20090.80 vs. 2.30\u2009\u00b1\u20090.70\u2009mmol\/L [97\u2009\u00b1\u200931 vs. 89\u2009\u00b1\u200927\u2009mg\/dL];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) and follow\u2010up (2.25\u2009\u00b1\u20090.59 vs. 2.12\u2009\u00b1\u20090.65\u2009mmol\/L [87\u2009\u00b1\u200923 vs., 82\u2009\u00b1\u200925\u2009mg\/dL];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02), with adjusted models confirming a persistent difference (0.17 [0.06, 0.27]\u2009mmol\/L [6.39 [2.39, 10.40]\u2009mg\/dL];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Females with T1D exhibit steeper early increases in adiposity and persistently higher LDL\u2010C levels compared to males, independent of age, glycemic control, and DKA status at diagnosis. These findings underscore the importance of sex\u2010specific metabolic monitoring and early intervention beginning at diagnosis to mitigate long\u2010term cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/pedi\/7996152","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:36:36Z","timestamp":1762918596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Based Differences in BMI and LDL\u2010C Trajectories Following Type 1 Diabetes Diagnosis in Youth"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3759-2778","authenticated-orcid":false,"given":"Emir","family":"Tas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetha","family":"Movva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Muzumdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-4555","authenticated-orcid":false,"given":"Ingrid","family":"Libman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Diabetes in America","author":"Secrest A. 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