{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:55Z","timestamp":1787756035794,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":176,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Diabetes"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Hypertriglyceridemia (HTG) in the setting of newly diagnosed diabetes is common in both adult and pediatric populations, as insulin deficiency promotes lipolysis and impairs triglyceride (TG) clearance. Severe HTG (defined as TG levels above 1000\u2009mg\/dL) in pediatric patients with new\u2010onset type 1 diabetes mellitus (T1D) is rare; the true incidence and sequela of this phenomenon have not been well characterized. We present a single\u2010center experience on severe HTG in pediatric patients with new\u2010onset T1D between 2013 and 2022 and summarize the cases previously reported in the literature. Our cases display variability in their presentation and in their association with high\u2010risk complications, such as acute pancreatitis. We discuss suggestions of early screening for HTG and pancreatitis in patients with protracted abdominal pain, and close monitoring of those identified to have significant HTG.<\/jats:p>","DOI":"10.1155\/pedi\/8425032","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T23:48:46Z","timestamp":1750981726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypertriglyceridemia in New\u2010Onset Type 1 Pediatric Diabetes"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4321-3742","authenticated-orcid":false,"given":"Colleen A.","family":"Macke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-821X","authenticated-orcid":false,"given":"Iman","family":"Al-Gadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-0112","authenticated-orcid":false,"given":"Sarah K.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini A.","family":"Nella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573400514666180117092707"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.19080\/CRDOJ.2019.10.555787"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.04.004"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0106"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/PIC-13053"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_281_16"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-200431"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0217"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3844"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301810"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.18544\/PEDM-21.02.0029"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198605000-00010"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2017-0008"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/293917"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.1111.x"},{"key":"e_1_2_12_16_2","first-page":"1","article-title":"Hypertriglyceridemia as a Complication of Severe Diabetic Ketoacidosis in Newly Diagnosed Diabetes - 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