{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:23:01Z","timestamp":1787296981506,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neutrophil\u2010to\u2010lymphocyte ratio (NLR) is a marker of systemic inflammation and has shown promise in assessing disease severity in chronic respiratory conditions including bronchiectasis. This study explores the association between NLR and clinical markers of bronchiectasis severity, including lung function and the Bronchiectasis Severity Index (BSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between NLR, lung function, and bronchiectasis severity in adults with noncystic fibrosis bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective single\u2010center study of adults with HRCT\u2010confirmed bronchiectasis identified from electronic health records. Demographic, spirometric, microbiological, BSI, and blood count data were collected. NLR was calculated from the first available complete blood count obtained during clinical stability. Correlation analyses were performed in an outlier\u2010truncated cohort, whereas multivariate general linear models and ordinal regression assessed independent associations with lung function and BSI severity categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 213 patients; 99 were male and 114 female, with a mean age of 53.9 \u00b1 20.4 years. Most patients had severe bronchiectasis by BSI category. Chronic\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      colonization was present in 33.8% and was associated with lower FEV\u2081% predicted. Median NLR was 2.89. NLR showed significant negative correlations with FEV\u2081% predicted, FVC% predicted, and FEV\u2081\/FVC ratio, but not with continuous BSI score. After adjustment for chronic\n                      <jats:italic>Pseudomonas<\/jats:italic>\n                      colonization, logNLR remained independently associated with FEV\u2081% predicted and FVC% predicted, but not with BSI score. In ordinal regression, NLR was not independently associated with BSI severity categories. Absolute eosinophil count was the only independent predictor of advanced BSI category.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR was associated with impaired lung function, but not independently with BSI. NLR may reflect physiological impairment but does not replace established severity tools such as BSI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/pm\/9920691","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:29:53Z","timestamp":1787293793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil\u2010to\u2010Lymphocyte Ratio in Bronchiectasis and Its Association With Disease Severity\u2014A Single\u2010Center Retrospective Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-567X","authenticated-orcid":false,"given":"Irfan","family":"Shafiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-8324","authenticated-orcid":false,"given":"Ali Saeed","family":"Wahla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-3092","authenticated-orcid":false,"given":"Mateen Haider","family":"Uzbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-6160","authenticated-orcid":false,"given":"Zaid","family":"Zoumot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-8342","authenticated-orcid":false,"given":"Mohamed","family":"Abuzakouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-6795","authenticated-orcid":false,"given":"Shuayb","family":"Elkhalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6933-5986","authenticated-orcid":false,"given":"Jahnavi","family":"Bodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5891-2768","authenticated-orcid":false,"given":"Said","family":"Isse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-19956-y"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026313"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20194514"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101399"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016371"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296838"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20240068"},{"key":"e_1_2_12_9_2","doi-asserted-by":"crossref","unstructured":"ShafiqI. WahlaA. S. UzbeckM. H. ZoumotZ. AbuzakoukM. ElkhalifaS. BodiJ. andIsseS. Neutrophil-to-Lymphocyte Ratio in Bronchiectasis and Its Association With Disease Severity \u2013 A Single Centre Retrospective Study 2025 preprint research square; May 2025https:\/\/doi.org\/10.21203\/rs.3.rs-6691002\/v1.","DOI":"10.21203\/rs.3.rs-6691002\/v1"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0179-2024"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/20018525.2024.2372901"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9728"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9874068"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1889OC"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-023-00668-w"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02543-z"}],"container-title":["Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/pm\/9920691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/pm\/9920691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/pm\/9920691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:29:54Z","timestamp":1787293794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/pm\/9920691"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/pm\/9920691"],"URL":"https:\/\/doi.org\/10.1155\/pm\/9920691","archive":["Portico"],"relation":{},"ISSN":["2090-1836","2090-1844"],"issn-type":[{"value":"2090-1836","type":"print"},{"value":"2090-1844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9920691"}}