{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:15:27Z","timestamp":1775283327894,"version":"3.50.1"},"reference-count":93,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["201812121226"],"award-info":[{"award-number":["201812121226"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373559"],"award-info":[{"award-number":["82373559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PPAR Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We are aimed at investigating the relationships among muscle mass, physical activity, and calcaneal bone mineral density (BMD) in female university students, and exploring the mediating role of muscle mass in the association between physical activity and calcaneal BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using stratified cluster sampling, 593 female university students aged 19\u201325 of different grades were selected. Anthropocentric characteristics, body composition, and calcaneal BMD were measured. Statistical methods including multiple linear\/binary logistic regression models, mediation analyses, sensitivity analyses, and subgroup analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The normal and abnormal BMD groups significantly varied in both total skeletal muscle mass (TSM) and total skeletal muscle mass index (TSMI) (t[TSM] = 3.216, t[TSMI] = 3.304,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), and also diverse in physical activity (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The increment in muscle mass might be related to an increase in BMD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [TSM] = 0.089,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [TSMI] = 0.265,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) and a decrease in the probability of abnormal BMD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [TSM] = \u22120.193,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [TSMI] = \u22120.682,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). The effect of physical activity on calcaneal BMD is significant (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u22120.109,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Muscle mass plays a mediating role in the relationship between physical activity and calcaneal BMD, and the subgroup mediation sensitivity analyses indicated that the mediation effect only in the overweight group had significant mediation effects and relatively high robustness (Rho = \u22120.2, R\n                      <jats:sup>2<\/jats:sup>\n                      _MR\n                      <jats:sup>2<\/jats:sup>\n                      _Y = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Muscle mass and physical activity both present a significant positive correlation with calcaneal BMD in female university students, and high activity level is a protective factor for abnormal BMD. Muscle mass performs a mediating role in the relationship of physical activity and calcaneal BMD in female university students of the overweight group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ppar\/5484324","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:39:00Z","timestamp":1775281140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediating Role of Muscle Mass in the Relationship Between Physical Activity and Bone Mass in Female University Students in China"],"prefix":"10.1155","volume":"2026","author":[{"given":"Jiaye","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shitian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhendi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0258-4827","authenticated-orcid":false,"given":"Xiaocui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-7342","authenticated-orcid":false,"given":"Yiran","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04030-x"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7108.2020.09.001"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09075-8"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7406.89"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674-2591.2011.01.002"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.16237\/j.cnki.cn44-1404\/g8.2004.04.014"},{"key":"e_1_2_14_7_2","first-page":"105","article-title":"Influence and Correlation of Different Sports Events on Bone Mineral Density and Body Composition of Female College Students (in Chinese)","volume":"36","author":"Mo Y. H.","year":"2014","journal-title":"Zhejiang Sport Science (in Chinese)"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.19582\/j.cnki.11-3785\/g8.2012.08.009"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7108.2016.02.008"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.16470\/j.csst.2007.02.005"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.13933\/j.cnki.2096-2134.2022.03.016"},{"key":"e_1_2_14_12_2","volume-title":"The Epidemiology of Calcaneal Fractures and Analysis of Damage Character (in Chinese)","author":"Su Y. L.","year":"2015"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06317-x"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-v99i12-30A"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0443-z"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7108.2018.01.009"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.7620\/zgfybj.j.issn.1001-4411.2017.15.17"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8126465"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001385"},{"key":"e_1_2_14_20_2","unstructured":"Council for International Organizations of Medical Sciences International Ethical Guidelines for Biomedical Research Involving Human Subjects 2016 https:\/\/cioms.ch\/wp-content\/uploads\/2021\/03\/International_Ethical_Guidelines_for_Biomedical_Research_Involving_Human_Subjects_2002.pdf."},{"key":"e_1_2_14_21_2","volume-title":"Declaration of Helsinki: 1964","author":"World Medical Association","year":"1964"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_2_14_23_2","unstructured":"World Health Organization Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis: Report of a WHO Study Group [Meeting Held in Rome From 22 to 25 June 1992] 1994 https:\/\/iris.who.int\/handle\/10665\/39142."},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.2307\/270922"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-3514.51.6.1173"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-9004.2011.00355.x"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.7507\/1672-2531.202204036"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2030-x"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.3321\/j.issn:1673-8225.2007.14.046"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.13877\/j.cnki.cn22-1284.2019.10.016"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674-2591.2018.01.013"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04748-x"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-7108.2019.07.012"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.03.002"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190104"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2014.964750"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070033"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa016"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32816e06f9"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116587"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2024.06.003"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci42285"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5244.2008"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3175"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2808-0"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47030158"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00918-9"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.09.001"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.08.003"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70136"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0209-0"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1414161"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa098"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0488"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01045"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.7506\/spkx1002-6630-20250128-205"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1444-x"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00050-0"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309133"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.1615\/critreveukargeneexpr.v19.i4.50"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0089"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1049"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-22-0530"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3868"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01834"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2244004.002"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2014.0585"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000001759"},{"key":"e_1_2_14_69_2","doi-asserted-by":"publisher","DOI":"10.1590\/1517-869220192503210258"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00486.x"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050608"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90011-K"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007496126098"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.09.008"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-020-01040-4"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2016.5992"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.12182\/20240160204"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674-2591.2022.02.013"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom15060893"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1998.87.3f.1463"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1040116"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11121669"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojpm.2019.92002"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-013-0060-y"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-018-0482-0"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-3010.2007.00670.x"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.12799\/jkachn.2010.21.3.333"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622200"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.11.024"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14183"},{"key":"e_1_2_14_91_2","first-page":"124","article-title":"Study on the Construction of Physical Fitness Promotion Model for College Students (in Chinese)","volume":"50","author":"Shao Y.","year":"2024","journal-title":"Journal of Chengdu Sport University (in Chinese)"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0036-36342009000700005"},{"key":"e_1_2_14_93_2","first-page":"613","article-title":"Normal-Weight Obesity and Bone Health in Asian Adolescents","volume":"39","author":"Lee Y. C.","year":"2021","journal-title":"Journal of Bone and Mineral Metabolism"}],"container-title":["PPAR Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ppar\/5484324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ppar\/5484324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ppar\/5484324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:39:21Z","timestamp":1775281161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ppar\/5484324"}},"subtitle":[],"editor":[{"given":"Rodrigo","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ppar\/5484324"],"URL":"https:\/\/doi.org\/10.1155\/ppar\/5484324","archive":["Portico"],"relation":{},"ISSN":["1687-4757","1687-4765"],"issn-type":[{"value":"1687-4757","type":"print"},{"value":"1687-4765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5484324"}}