{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:29:21Z","timestamp":1786602561214,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":223,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017052","name":"National Natural Science Foundation of China-Liaoning Joint Fund","doi-asserted-by":"publisher","award":["82271260"],"award-info":[{"award-number":["82271260"]}],"id":[{"id":"10.13039\/100017052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7232103"],"award-info":[{"award-number":["7232103"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical observations have suggested an association between a high\u2010fat diet (HFD) and neuropathic pain (NP). Studies also revealed that maresin 1 (MaR1) can regulate macrophage phagocytosis, modulate tissue repair and inflammatory resolution, and influence the progression of NP. However, the specific regulatory mechanisms of MaR1 in HFD\u2010induced NP remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to explore the effect of MaR1 on neuroinflammation in mice with NP induced by an HFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A tibial nerve crush model with a HFD was used to establish HFD\u2010induced chronic pain. The paw withdrawal threshold (PWT), which reflects mechanical allodynia, was measured to evaluate changes in pain\u2010related behavior. Immunofluorescence was used to detect the relative number of macrophages and microglia, and the expression of growth\u2010associated protein 43 (GAP43), while qPCR was used to measure the levels of proinflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HFD consumption exacerbates nerve injury\u2013induced NP formation and upregulates GAP43 expression. Macrophage infiltration and proinflammatory cytokine expression were increased in the DRGs of HFD\u2010induced nerve injury mice. Intrathecal injection of the specialized proresolving mediator MaR1 alleviated nerve injury\u2013induced chronic pain and decreased GAP43 expression in HFD\u2010fed mice. Furthermore, MaR1 decreased proinflammatory macrophage migration in the damaged tibial nerves and DRGs of HFD\u2010induced nerve injury model mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The specialized proresolving mediator MaR1 can reduce neuroinflammation and GAP43 expression in the DRG and injured nerve fibers and alleviate NP in HFD\u2010fed mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/1157250","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:02:32Z","timestamp":1786600952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Specialized Proresolving Mediator Maresin 1 Alleviated Neuropathic Pain Exacerbated by High\u2010Fat Diet via Regulating 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