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Genome\u2010wide association study (GWAS) data from FinnGen R10 were integrated with blood\u2010derived DNA methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) datasets. Associations were evaluated by colocalization and replication in UKBB (G6_TRINEU) and FinnGen R12. Drug\u2010target MR analysis used blood eQTL variants as proxies for gene expression. GEO transcriptomic and single\u2010cell RNA sequencing (scRNA\u2010seq) datasets and GTEx brain tissue eQTL data provided expression and tissue\u2010level validation. Functional enrichment, protein\u2013protein interaction network, and druggability analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SMR analysis identified 238 mQTLs (127 genes), 30 eQTLs, and 3 pQTLs associated with TN. Colocalization supported 96 mQTLs (23 genes), 18 eQTLs, and 3 pQTLs, with 42 mQTLs and the\n                      <jats:italic>CNOT7<\/jats:italic>\n                      eQTL validated in UKBB.\n                      <jats:italic>POMGNT2<\/jats:italic>\n                      showed genetically predicted associations with TN at both gene and protein levels. Integrative analysis highlighted\n                      <jats:italic>ATP6V0E2, PLAT,<\/jats:italic>\n                      and\n                      <jats:italic>VKORC1<\/jats:italic>\n                      with evidence of epigenetic regulation. Drug\u2010target MR provided supportive evidence that genetically proxied expression of\n                      <jats:italic>CNOT7<\/jats:italic>\n                      and\n                      <jats:italic>PLAT<\/jats:italic>\n                      may be associated with lower TN risk. Transcriptomic validation showed downregulation of\n                      <jats:italic>ATP6V0E2, PLAT,<\/jats:italic>\n                      and\n                      <jats:italic>CNOT7<\/jats:italic>\n                      after trigeminal nerve injury. Brain eQTL analysis supported the association of\n                      <jats:italic>CNOT7<\/jats:italic>\n                      with TN across multiple brain regions. scRNA\u2010seq revealed cell\u2010type\u2010specific expression patterns of prioritized genes in trigeminal ganglion tissues. Functional enrichment indicated involvement in stress response, metabolism, and genome maintenance pathways. PPI analysis identified six hub genes:\n                      <jats:italic>ABCB1, COMT, GFM1, MDH2, NRAS,<\/jats:italic>\n                      and\n                      <jats:italic>TXN<\/jats:italic>\n                      . Druggability analysis showed that\n                      <jats:italic>ATP6V0E2, PLAT,<\/jats:italic>\n                      and\n                      <jats:italic>VKORC1<\/jats:italic>\n                      are targetable by existing drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study prioritizes purine metabolism\u2013linked genes showing genetically supported associations with TN and highlights potential biological pathways and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/1640039","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:27:01Z","timestamp":1786084021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Purine Metabolism\u2013Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-6692","authenticated-orcid":false,"given":"Simin","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0547-4377","authenticated-orcid":false,"given":"Jiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0706-802X","authenticated-orcid":false,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5608-8244","authenticated-orcid":false,"given":"Xili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1101-6408","authenticated-orcid":false,"given":"Xiangming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3675-1279","authenticated-orcid":false,"given":"Peiyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8675-0325","authenticated-orcid":false,"given":"Yaping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5763-9292","authenticated-orcid":false,"given":"Libiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8644-6121","authenticated-orcid":false,"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1731-6354","authenticated-orcid":false,"given":"Zhangxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ncl.2022.09.001","article-title":"Trigeminal Neuralgia: Diagnosis and Treatment","volume":"41","author":"Allam A. 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