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Although pharmacological and surgical interventions provide partial relief, effective treatment for PD\u2010associated pain remains limited. Pharmacopuncture, an injection of herbal extracts into acupoints, has demonstrated potential in pain management. This study evaluated the analgesic and neuroprotective effects of SU\u2010Eohyeol pharmacopuncture (SUEHP) in a 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2013induced PD mouse model. C57BL\/6N male mice received repeated intraperitoneal injections of MPTP to induce PD\u2010related pain. SUEHP was bilaterally administered at the GB34 acupoint or a control site. Pain sensitivity and motor function were evaluated, followed by postsacrifice histological assessments. Administration of SUEHP at GB34 significantly attenuated MPTP\u2010induced mechanical hypersensitivity and spinal c\u2010Fos expression, enhanced tyrosine hydroxylase and brain\u2010derived neurotrophic factor expression in the substantia nigra, and partially restored motor function. However, cotreatment with a CB1 or PPAR\u03b3 antagonist eliminated these analgesic and neuroprotective effects, suggesting that SUEHP mediates its effects through specific pathways. Transcriptomic profiling of the midbrain and spinal cord revealed that SUEHP modulated inflammation, dopaminergic neurogenesis, and synaptic signaling pathways, which were typically reversed using cotreatment with CB1 or PPAR\u03b3 antagonist. Collectively, SUEHP alleviates PD\u2010associated pain and neurodegeneration through CB1 and PPAR\u03b3 pathways, suggesting its potential as a safe, noninvasive complementary therapy for PD symptom management.<\/jats:p>","DOI":"10.1155\/prm\/3334432","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T13:16:29Z","timestamp":1780233389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SU\u2010Eohyeol Pharmacopuncture Ameliorates Parkinson\u2019s Disease\u2013Associated Pain via the CB1 and PPAR\u03b3 Pathways in an MPTP\u2010Induced Mouse Model"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5795-0069","authenticated-orcid":false,"given":"Jung Im","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5311-6138","authenticated-orcid":false,"given":"Heerim","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-4998","authenticated-orcid":false,"given":"Yousang","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7997-7663","authenticated-orcid":false,"given":"Hyungjun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-0742","authenticated-orcid":false,"given":"Sang-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-708X","authenticated-orcid":false,"given":"No Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-181474"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2024.12.008"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22643"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab001"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-024-00169-z"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870010106"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230112"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22716"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2023.1240379"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.8"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-202069"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8426-y"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2205132"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21667"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20031776"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3831\/kpi.2023.26.3.227"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x92000369"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2018.04.004"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403245"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2005-2901(10)60029-5"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2018.05.010"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000041733"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000034212"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2025.103160"},{"key":"e_1_2_13_27_2","first-page":"13","article-title":"Neuroprotective Effects of Neutral Pharmacopuncture for Blood Stasis and Tangguisusangami-Tang (Dangguixusanjiawei-Tang) in the Experimental Traumatic Brain Injury Rats","volume":"20","author":"Jong I. 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