{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:06:35Z","timestamp":1784192795483,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medication\u2010overuse headache (MOH) is a disabling secondary headache arising from frequent acute medication intake in individuals with preexisting primary headache. Behavioral and psychosocial factors may perpetuate medication overuse. As a reduction of acute medication intake is essential for remission, educational and behavioral interventions are commonly used; however, their effectiveness remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically evaluate the effectiveness of educational and behavioral interventions on acute medication use, headache frequency, and headache\u2010related disability in patients with MOH, and to assess short\u2010 and longer\u2010term outcomes compared to usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception to January 2026 for randomized controlled trials evaluating educational or behavioral interventions in adults with MOH. Outcomes included reduction of acute medication use, headache frequency, and headache\u2010related disability. Random\u2010effects meta\u2010analyses were performed where appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six trials (610 participants) were included. Brief educational interventions were associated with clinically meaningful reductions in acute medication use and headache frequency. Multiple\u2010session interventions, compared to minimal intervention, were associated with additional mean reductions in acute medication use of approximately 3\u2009days per month and in headache frequency of 2.6\u2009days per month at 3\u2009months and 0.8\u2009days per month at 12\u2009months; however, between\u2010group differences were not statistically significant. Substantial heterogeneity was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Brief educational interventions may be considered as a potentially useful component of MOH care. Multisession interventions may offer additional benefit but remain inconclusive because of heterogeneity and limited evidence. Further high\u2010quality trials are needed to define optimal strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/3699422","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:42:27Z","timestamp":1784191347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Educational and Behavioral Interventions on Medication\u2010Overuse Headache: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Pannathat","family":"Soontrapa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-2578","authenticated-orcid":false,"given":"Prut","family":"Koonalintip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pitchayaporn","family":"Sornplang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-5207","authenticated-orcid":false,"given":"Benjamin R.","family":"Wakerley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/life14091146"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0544-2"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12794"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2025.2605079"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1738"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201518"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1851"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/15291006211008157"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14010"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-021-10038-6"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.7090"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0728-z"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13101432"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00415-0"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413515336"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03094.x"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15256"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01630-0"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(05)85119-7"},{"key":"e_1_2_12_23_2","volume-title":"Health Behavior: Theory, Research, and Practice","author":"Glanz K.","year":"2015"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_12_25_2","doi-asserted-by":"crossref","DOI":"10.1002\/9781119536604","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. P. T.","year":"2019"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_12_28_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-21416-0","volume-title":"Meta-Analysis With R, (Use R!)","author":"Schwarzer G.","year":"2015"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308548"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-021-01758-3"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0679-9"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1500"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-01982-9"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12970"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-10"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417737779"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13318"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58010044"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14914"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-022-00200-0"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0965-4"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02237-3"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00600-x"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-022-01023-z"},{"key":"e_1_2_12_48_2","doi-asserted-by":"crossref","DOI":"10.23970\/AHRQEPCCER270","volume-title":"Behavioral Interventions for Migraine Prevention","author":"Treadwell J. R.","year":"2024"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1383"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01711.x"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00990-0"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000504"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0240-0"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-007-0361-3"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614522683"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.08.015"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2025.2596783"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01224-8"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/3699422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/prm\/3699422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/3699422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:42:29Z","timestamp":1784191349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/prm\/3699422"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/prm\/3699422"],"URL":"https:\/\/doi.org\/10.1155\/prm\/3699422","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3699422"}}