{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:39:24Z","timestamp":1780789164066,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":338,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1711800"],"award-info":[{"award-number":["2019YFC1711800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate and compare the safety and efficacy of two treatments for cervical spondylosis. One treatment involves the use of electronic wrist\u2013ankle acupuncture, in combination with Tuina, while the other treatment involves using traditional wrist\u2013ankle acupuncture, along with Tuina. The objective was to provide evidence\u2010based support for the treatment of cervical spondylosis using innovative medical device E\u2010WAA combined with Tuina and provide a better treatment option for patients with cervical spondylosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 164 patients with cervical spondylosis from June 2021 to December 2022 were randomly assigned to a control group and an experimental group. The control group received traditional wrist\u2013ankle acupuncture combined with Tuina, while the experimental group received the electronic wrist\u2013ankle acupuncture combined with Tuina. Both groups underwent treatment twice a week for a total of 3\u2009weeks. The primary outcome measure was the improvement rate of visual analog scale score, while the secondary outcome measures were the Neck Disability Index score and cervical range of motion. Safety measures included the recording of adverse reactions during treatment and subjective evaluation of the treatment methods by the patients. Clinical data were analyzed from January to March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Both treatment modalities demonstrated improvements in pain and cervical function. There was no significant difference in the VAS improvement rate between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.593). However, the electronic wrist\u2013ankle acupuncture combined with Tuina showed an additional benefit in reducing the NDI scores compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.017). During the study, no adverse reaction was reported, and 83.75% of patients considered the electronic wrist\u2013ankle acupuncture device to be safe.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both the electronic wrist\u2013ankle acupuncture combined with Tuina and the traditional wrist\u2013ankle acupuncture combined with Tuina showed significant therapeutic effects on cervical spondylosis. In comparison with the traditional wrist\u2013ankle acupuncture, the electronic wrist\u2013ankle acupuncture offers advantages such as noninvasiveness, controllability, and autonomous operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These findings suggest that the electronic wrist\u2013ankle acupuncture can serve as an adjunctive therapeutic approach for patients with cervical spondylosis, providing a more convenient treatment option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical Trial Registry: ChiCTR2200056394.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/3949302","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:12:20Z","timestamp":1764997940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Transcutaneous Acupoint Electrical Stimulation in the Treatment of Cervical Spondylosis: A Multicenter Randomized Open\u2010Labeled Controlled Clinical Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-1971","authenticated-orcid":false,"given":"Lele","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengcheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-3690","authenticated-orcid":false,"given":"Jiahao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-5567","authenticated-orcid":false,"given":"Ping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-5242","authenticated-orcid":false,"given":"Fanfu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2234-0"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m791"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2003558"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102534"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.1057290"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001299"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2020.0181"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1329.2020.05002"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.46538"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(18)30982-8"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203949"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318192ce39"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002071"},{"key":"e_1_2_13_14_2","volume-title":"Wan Huai Zhen","author":"Ling C. Q.","year":"2017"},{"key":"e_1_2_13_15_2","volume-title":"Acupuncture and Moxibustion Therapies","author":"Chi W. Y.","year":"2020"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2020.101170"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9946548"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1923-9"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2023.02.001"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2373-0513"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.138966"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnac141"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/476457"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBCAS.2020.3039063"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3379-3"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/10582452.2014.907852"},{"key":"e_1_2_13_27_2","first-page":"271","article-title":"Clinical Observation of the Message of Bachuo Rounian Improving the VAS Pain Score of External Humeral Epicondylitis","volume":"36","author":"Wang H. Y.","year":"2017","journal-title":"Journal of Tianjin University of Traditional Chinese Medicine"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2018.8131"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2009.2930"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.12875"},{"key":"e_1_2_13_31_2","first-page":"1419","article-title":"Analgesic Effect of wrist-ankle Acupuncture and Its Impact on Plasma \u03b2-EP and SP Contents in Patients with Cervical Spondylosis","volume":"37","author":"Bi C. P.","year":"2018","journal-title":"Shanghai Zhen Jiu Za Zhi"},{"key":"e_1_2_13_32_2","article-title":"Non-Inferiority Design Sample Size Estimation\u2014Counting Index","volume":"24","author":"Ying L. X.","year":"2016","journal-title":"Chinese Journal of Interventional Cardiology"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/ajp.0000000000000999"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.S351320"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.0517"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2023.0021"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/261709"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac59a1"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-020-0846-1"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2110098"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2020.33.2.121"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/3949302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/prm\/3949302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/prm\/3949302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:18:37Z","timestamp":1772957917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/prm\/3949302"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/prm\/3949302"],"URL":"https:\/\/doi.org\/10.1155\/prm\/3949302","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3949302"}}