{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:17:26Z","timestamp":1769120246461,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complex regional pain syndrome (CRPS) is a disabling condition requiring long\u2010term treatment. This study evaluated long\u2010term outcomes in CRPS patients compared to posttraumatic neuralgia (PN) and nociceptive limb pain (NLP) 1\u20135\u2009years after diagnosis and treatment initiation in a tertiary clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with CRPS lasting more than 1\u2009year (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009116), PN (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200968), or NLP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975) participated in a standardized telephone interview assessing pain intensity, functional impairment, neglect\u2010like symptoms, and disability in daily life and work.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PN patients had higher pain intensity compared to CRPS (NRS 5.7\u2009\u00b1\u20092.1 vs. 4.5\u2009\u00b1\u20092.6; main effect:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005; post hoc test:\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Functional outcomes varied significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). CRPS patients showed the highest rate of severe impairment (71%), especially in those with \u2265\u20093 clinical signs, while outcome was better in NLP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.027), especially in part\u2010time workers. The global impression of disability varied between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.044): PN patients reported a high level of severe disability (70%), while CRPS had the most subjects with \u201cnone\/slight\u201d disability (23%). Pain and function were tightly linked to perceived disability in all groups. Neither the neglect\u2010like total score (CRPS: 2.4 (2.2\u20132.6); neuralgia: 2.5 (2.3\u20132.7); NLP: 2.2 (1.9\u20132.5);\n                      <jats:italic>p<\/jats:italic>\n                      = 0.055) nor the working ability differed between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.397); however, only in CRPS, neglect\u2010like symptoms were associated with higher pain intensity and global disability, as well as lower functional outcome. CRPS patients treated with corticosteroids (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955) had more positive clinical signs at baseline and poorer outcomes than patients without corticosteroids (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term impairment, work\u2010related, and global disability in CRPS were similar to those of neuralgia and NLP patients treated in a tertiary pain clinic. Despite shorter disease duration, CRPS patients more often report severe disability, while pain is comparable to other chronic limb pain courses. More pronounced positive signs in CRPS at baseline are associated with poor outcomes. These findings emphasize the heterogeneous course of CRPS and the importance of individualized multidimensional approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/4722836","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:13:37Z","timestamp":1769058817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcome of Complex Regional Pain Syndrome versus Limb Pain of Other Origin: Results From a Telephone Survey With up to 5\u2010year Follow\u2010Up"],"prefix":"10.1155","volume":"2026","author":[{"given":"K\u00fcbra","family":"Arslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schwarzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-744X","authenticated-orcid":false,"given":"Christoph","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Butry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-3167","authenticated-orcid":false,"given":"Johannes","family":"Forsting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-9414","authenticated-orcid":false,"given":"Elena","family":"Enax-Krumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2115-6"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00169.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12730"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000282"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000234"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz030"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.813"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2196"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181a11623"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.06.003"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1953"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181c20207"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.039"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw147"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199606)29:6:602::AID-AJIM4>3.0.CO;2-L"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/9993438"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.04.010"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00076-7"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1362"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001210"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00076-0"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2025"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001180"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2116"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001217"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1650295"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.09.008"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001173"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw214"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab226"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12092140"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.8.929"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e318239e0ef"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0748-8"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S400659"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S278614"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.12.017"}],"container-title":["Pain 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