{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:30:46Z","timestamp":1792539046674,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":177,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to describe pain characteristics in patients diagnosed with Ehlers\u2013Danlos syndrome (EDS) or hypermobility spectrum disorders (HSD) and to identify factors associated with moderate to severe pain at diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010six patients were retrospectively identified through the Ce.Ma.R.S. registry (2017\u20132022). Pain intensity was assessed at first evaluation using a Numeric Rating Scale (0\u201310). Patients were grouped into no\/mild pain and moderate\/severe pain. Clinical and demographic data were collected, and variables significant in univariate analysis were included in multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At diagnosis, 49% of patients reported moderate to severe pain. Independent predictors were older age (OR\u2009=\u20091.06; 95% CI: 1.03\u20131.10), diagnosis of hypermobile EDS (OR\u2009=\u20096.25; 95% CI: 1.31\u201329.74), and headache (OR\u2009=\u20093.97; 95% CI: 1.14\u201313.82). Use of pain medications, particularly paracetamol and NSAIDs, was strongly associated with higher pain severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pain is a common and early symptom in EDS and HSD. Older patients, those with hypermobile EDS, and those with headache are at greater risk of severe pain. Early, multidisciplinary pain management, including pharmacological treatment, physiotherapy, and headache\u2010specific strategies, should be prioritized to improve outcomes and reduce long\u2010term disability.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT04133272\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/prm\/6664142","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T10:32:07Z","timestamp":1782556327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Pain in Patients Diagnosed With Ehlers\u2013Danlos Syndrome and Hypermobility Spectrum Disorders. An Observational Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-9927","authenticated-orcid":false,"given":"Mattia","family":"Morri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morena","family":"Tremosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-9261","authenticated-orcid":false,"given":"Cristiana","family":"Forni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-341X","authenticated-orcid":false,"given":"Alice","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-7741","authenticated-orcid":false,"given":"Elena","family":"Pedrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5691-0786","authenticated-orcid":false,"given":"Alessia 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